In 2019, hepatitis C virus (HCV) infection was the leading cause of death among 60 notifiable infectious diseases in the US and contributed to increasing rates of liver-related mortality.
1-3 This infection disproportionately affects American Indian and Alaska Native individuals, with an estimated incidence of 2.9 per 100 000 population, more than twice that of all other racial/ethnic groups
1,4; the rate of HCV-related deaths in this population is 10.2-fold higher than that in the general US population.
5