Karolina Samarzewska

Dr. Karolina Samarzewska

orcid

Research Focus & Metrics

Academic Career Length

6Years (2021-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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16 November 2021 in Healthcare
Verified
Journal Article
Open access
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EKEzgi Kolay
Ezgi Kolay
ABAleksandra Bykowska-Derda
Aleksandra Bykowska-Derda
SASafa Abdulsamad
Safa Abdulsamad
MKMałgorzata Kałużna
Małgorzata Kałużna
KSKarolina Samarzewska
Karolina Samarzewska
Magdalena Czlapka- MatyasikMagdalena Czlapka- Matyasik
Magdalena Czlapka- Matyasik
Eating speed (ES) as a dietary behaviour has become a widely discussed factor for weight management and obesity. This study analysed the relationship between ES and anthropometric indicators of obesity, including BMI and waist circumference (WC) in adults. A search conducted of PubMed, Web of Science, Science Direct and Scopus found six longitudinal studies and fifteen cross-sectional studies published for further analysis. A quality assessment was performed with the MINORS checklist. Eight studies were included in the meta-analysis and almost all reviewed studies showed that ES was associated with BMI, and non-fast eaters had significantly lower BMI than fast eaters. Therefore, it was assumed that slowing down the ES may be an effective strategy for weight management and lowering obesity risk. There was also an association between WC and ES. Assessment of eating speed can be included in nutrition surveys to analyse obesity risk. More broadly, research is also needed to establish a validated and standardised methodology to determine eating speed. Further research needs to examine the links between eating speed, obesity, ethnicity, sex, food culture and chronic diseases.

23 July 2021 in Pharmaceuticals
Verified
Journal Article
Open access
PDF file
SSSzymon Sip
Szymon Sip
MPMagdalena Paczkowska-Walendowska
Magdalena Paczkowska-Walendowska
NRNatalia Rosiak
Natalia Rosiak
Andrzej MiklaszewskiAndrzej Miklaszewski
Andrzej Miklaszewski
KGKatarzyna Grabańska-Martyńska
Katarzyna Grabańska-Martyńska
Judyta Cielecka-PiontekJudyta Cielecka-Piontek
Judyta Cielecka-Piontek
Chitosan is a valued excipient due to its biocompatibility properties and increasing solubility of poorly water-soluble drugs. The research presented in this paper concerns the preparation of binary combinations of chitosan (deacetylated chitin) with carvedilol (beta-blocker) to develop a formulation with a modified carvedilol release profile. As part of the research, six physical mixtures of chitosan with carvedilol were obtained and identified by spectral (PXRD, FT-IR, and Raman), thermal (DSC), and microscopic (SEM) methods. The next stage of the research estimated the profile changes and the dissolution rate for carvedilol in the obtained drug delivery systems; the reference sample was pure carvedilol. The studies were conducted at pH = 1.2 and 6.8, simulating the gastrointestinal tract conditions. Quantitative changes of carvedilol were determined using the developed isocratic UHPLC-DAD method. Established apparent permeability coefficients proved the changes in carvedilol’s permeability after introducing a drug delivery system through membranes simulating the gastrointestinal tract and skin walls. A bioadhesive potential of carvedilol–chitosan systems was confirmed using the in vitro model. The conducted research and the obtained results indicate a significant potential of using chitosan as an excipient in modern oral or epidermal drug delivery systems of carvedilol.