This study sought to evaluate the possibility of using grape pomace, a waste material from wine production, for the preparation of cosmetic components. Following the existing clear research trend related to improving the safety of cleansing cosmetics, an attempt was made to determine the possibility of preparing model shower gels based on grape pomace extract. A new method for producing cosmetic components named loan chemical extraction (LCE) was developed and is described for the first time in this paper. In the LCE method, an extraction medium consisting only of the components from the final product was used. Thus, there were no additional substances in the cosmetics developed, and the formulation was significantly enriched with compounds isolated from grape pomace. Samples of the model shower gels produced were evaluated in terms of their basic parameters related to functionality (e.g., foaming properties, rheological characteristics, color) and their effect on the skin. The results obtained showed that the extracts based on waste grape pomace contained a number of valuable cosmetic compounds (e.g., organic acids, phenolic compounds, amino acids and sugars), and the model products basis on them provided colorful and safe natural cosmetics.

Modern agriculture uses pesticides to improve the quality and quantity of crops. However, pesticide residues can remain on agricultural products, posing very serious risks to human health and life. It is recommended to wash fruits and vegetables before consumption. To assess the removal efficacy of pesticide residue, a sensitive and reliable method based on ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) was developed and optimized for the simultaneous determination of four pesticide residues (acetamiprid, boscalid, pyraclostrobin, and pendimethalin). Isotope-labeled standards were used to validate the method in terms of recovery, linearity, matrix effects, precision, and sensitivity. The mean recovery values for both low-quality control (LQC) and high-quality control (HQC) transitions were in the range of 89–105%, and the intra-day precision was less than 13.7%. The limits of detection (LOD) and quantification (LOQ) were 0.003 mg/kg and 0.01 mg/kg, respectively. The proposed method is suitable for evaluating the quality of detergents for removing pesticide residues from fruit surfaces.

The present study aimed to evaluate the possibility of using micellar and solvent loan chemical extraction (LCE) to isolate valuable components from grapevine leaf buds, subsequently utilizing them to prepare functional and safe-to-use cosmetic preparations, specifically facial serums. An aqueous solution of polyglyceryl-4 laurate/sebacate and polyglyceryl-6 caprylate/caprate was employed for a micellar LCE, while an aqueous solution of 1,3-propanediol was used for a solvent LCE. Importantly, the extraction medium was exclusively comprised of components from the designed final cosmetic product. Consequently, no additional substances were present in the cosmetics developed, and the formulation was notably enhanced by compounds extracted from grapevine buds. The antioxidant properties and compound characterization of the obtained micellar (SurfE) and solvent (SolvE) extracts based on grapevine buds were tested and compared. UPLC-MS/MS results indicated that the extracts were rich in phenolic and flavonoid compounds, exhibiting antioxidant activity as measured using the DPPH and ABTS scavenging ability. The extracts were used to prepare model facial serums, which underwent evaluation based on fundamental functionality-related parameters (e.g., rheological characteristics and color) and their impact on the skin through cytotoxicity assessment. The results demonstrated that facial serums with extracts based on grapevine buds provided safe, natural cosmetics.