Real-time spot spraying technology has the potential to reduce herbicide costs and slow herbicide resistance. However, few studies exist on the efficacy of this technology in the Pacific Northwest (PNW). This research compared the herbicide efficacy (reduction in weed density and cover) of WEED-IT and WeedSeeker spot spraying systems to uniform spraying in fallow and postharvest in 2019 and 2020. Weed community types included naturally occurring weeds, natural + Russian thistle (Salsola tragus L.), or natural + kochia (Bassia scoparia (L.) A. J. Scott). Herbicides included glyphosate or the pre-mix bromoxynil + pyrasulfotole. Additionally, herbicide efficacy was studied with short stubble (~10 cm), tall stubble (~25 cm), and normal stubble (~20 cm) with chaff and straw removed. In fallow, herbicide efficacy was 1.5 times higher for uniform applications than for WEED-IT or WeedSeeker in 2019 and 2020. Herbicide efficacy was also 1.9 times higher for uniform applications in postharvest in 2019 but no differences were found in 2020. The weed community impacted herbicide efficacy but herbicide efficacy did not differ between residue management treatments. Finally, WEED-IT and WeedSeeker used 53% less herbicide volume in comparison to uniform applications. This research demonstrated that spot spraying technology can be efficacious and economical for growers in the PNW.