Optic neuritis, inflammation of the optic nerve, can cause visual impairment through retinal nerve fiber layer (RNFL) degeneration. Optical coherence tomography could serve as a sensitive noninvasive tool for measuring RNFL thickness and evaluating the neuroprotective effects of treatment. We conducted a meta-analysis to compare RNFL loss between novel add-on treatments and corticosteroid therapy at least 3 months after acute optic neuritis. The outcome measures were mean differences (MDs) in (1) RNFL thickness compared with the baseline in the affected and unaffected eye and (2) LogMAR visual acuity (VA). Seven studies involving five novel agents (memantine, erythropoietin, interferon-beta, phenytoin, and clemastine) were analyzed. When compared with the baseline RNFL thickness of the affected eye, the neuroprotective effects of novel add-on treatments could not be demonstrated. The difference in visual outcomes was also not significant between the two treatment groups. One study revealed that phenytoin has the potential to alleviate RNFL loss when the baseline thickness of the unaffected eye is considered. Larger randomized controlled trials with suitable outcome measures are warranted to evaluate the neuroprotective effects of novel treatments. Further studies should also tailor therapies to specific patient populations and investigate a more targeted treatment for acute optic neuritis.

Background and Objectives: Scleral lenses are widely used for visual rehabilitation in keratoconus patients, but their long-term effects on corneal tomography remain unclear. This study aims to evaluate the impact of 12-month scleral lens wear on corneal tomography in keratoconus patients through a case-controlled design. Materials and Methods: This retrospective study included 220 keratoconus patients, of whom 10 eyes were treated with SoClear (Brighten Optix Corporation, Taipei, Taiwan) mini-scleral lenses for over one year (SL group). A control group of 14 eyes was matched using Mahalanobis distance matching based on anterior maximum keratometry (K_max) and age. Both groups were evaluated at baseline and 12 months. Corneal tomography was assessed using the Pentacam HR (Oculus, Wetzlar, Germany), analyzing parameters such as anterior and posterior corneal curvature, thinnest corneal thickness (TCT), and higher-order aberrations. Generalized estimating equations (GEEs) were employed to assess the time-by-treatment effect between the two groups. Results: The SL group included 10 eyes from eight patients (seven males, one female; mean age 30.40 ± 6.52 years), while the control group included 14 eyes from 11 patients (three males, wight females; mean age 27.43 ± 8.11 years). Best corrected visual acuity with spectacles improved significantly with scleral lenses (p = 0.011) and remained stable (p = 0.044) at 12 months. Significant interaction effects were found in Ambrósio relational thickness (p = 0.006), posterior radius curvature (p = 0.047), posterior mean keratometry (p = 0.019), posterior flat keratometry (p = 0.023), and thinnest corneal thickness angle (p = 0.023); the SL group demonstrated less progression in these parameters compared to the control group. Conclusions: This case-controlled study highlights the 12-month impact of scleral lenses on keratoconus, showing improved visual acuity compared to spectacles, stabilized posterior corneal curvature, and maintained corneal thickness. Further prospective studies with larger cohorts are needed to assess scleral lens effect on keratoconus progression.