Cruz Vargas-De-León is a professor of applied maths and biostatistics and a researcher in medical sciences. His research interests are biostatistical and biomathematical modeling for health. He has published more than 70 articles, with 55 in high-impact and JCR-indexed journals. He has participated in the validation of surveys, randomized controlled trials, systematic reviews, and meta-analyses, the construction of indices in medicine, and the identification of immunological biomarkers in cancer and epidemiological studies. He is also a mathematical modeler of biological processes (infectious diseases, social epidemics, viral infections, antiviral immune response, and mutualistic interactions between populations). He has participated in the Bayesian estimation of the parameters of differential equation models. He has contributed to the theory of Lyapunov stability in differential equations of fractional order. He received a certificate for highly cited research in mathematical biosciences (2016, Elsevier) and was awarded the Guillermo Soberón Guerrero State Award for Merit in Science and Technology (2016). His biography appeared in Marquis Who's Who in the World, Issue 30 (2013). Two of his articles received "Excellent Paper" awards from the National Program for Research Evaluation (2011‒2014) in Italy. He has been a member of the National System of Researchers of Mexico’s National Council of Science and Technology since 2015.