Lola Amorós-Galicia

Mrs. Lola Amorós-Galicia

University of Barcelona
orcid

Research Focus & Metrics

Academic Career Length

7Years (2020-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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21 September 2022 in Pharmaceutics
Verified
Journal Article
Open access
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LALola Amorós-Galicia
Lola Amorós-Galicia
Anna Nardi RicartAnna Nardi Ricart
Anna Nardi Ricart
CVClara Verdugo-González
Clara Verdugo-González
CACarmen Martina Arroyo-García
Carmen Martina Arroyo-García
Encarna Garcia-MontoyaEncarna Garcia-Montoya
Encarna Garcia-Montoya
MSMarc Suñé-Pou
Marc Suñé-Pou
Although some methods for measuring bioadhesion/mucoadhesion have been proposed, a standardized method is not yet available. This is expected to hinder systematic comparisons of results across studies. This study aimed to design a single/systematic in vitro method for measuring bioadhesion/mucoadhesion that is applicable to various pharmaceutical dosage forms. To this end, we measured the peak force and work of adhesion of minitablets, pellets, and a bioadhesive emulsion using a texture analyzer. Porcine tissue was used to simulate human stomach/skin conditions. The results of these formulations were then compared to those for formulations without the bioadhesive product. We conducted a case study to assess the stability of a bioadhesive emulsion. The results for the two parameters assessed were contact time = 60 s and contact force = 0.5 N at a detachment speed of 0.1 mm/s. Significant differences were observed between the bioadhesive and control formulations, thus demonstrating the adhesive capacity of the bioadhesive formulations. In this way, a systematic method for assessing the bioadhesive capacity of pharmaceutical dosage forms was developed. The method proposed here may enable comparisons of results across studies, i.e., results obtained using the same and different pharmaceutical formulations (in terms of their bioadhesion/mucoadhesion capacity). This method may also facilitate the selection of potentially suitable formulations and adhesive products (in terms of bioadhesive properties).

1 April 2020 in Journal of Photochemistry and Photobiology B: Biology
Verified
Journal Article
Closed access
MSMyriam Sohn
Myriam Sohn
LALola Amorós-Galicia
Lola Amorós-Galicia
SKStanislaw Krus
Stanislaw Krus
KMKarine Martin
Karine Martin
BHBernd Herzog
Bernd Herzog