The theme of urban regeneration is currently one of the main actions of transformation policies. It presents an opportunity for cities’ design, in particular historical centers, through joint actions aimed at creating synergies and connections between social, political, economic, and environmental aspects. It also becomes an opportunity to enhance the huge and complex Cultural Heritage, full of architectural values, memory, and history. At the same time, it appears increasingly inadequate and obsolete compared to the new needs of a changing society, of regulatory aspects, and of a general compatible approach to intervention to the more general policies of sustainable development, as required by the 2030 Agenda for Sustainable Development. A total of two case studies of the reuse and enhancement of hospital buildings of the University of Pavia are presented, which has a large building heritage spread throughout the city. In recent years, owing to the opportunities offered by funding, it has started transformation policies on some abandoned buildings through projects based on an interdisciplinary approach and a participatory design strategy. The article testifies to a potential method of intervention that can be exported to other contexts, after a previous test of the compatibility on the existing and on the urban context.

The architectural heritage of the 20th century has proved to be highly vulnerable to the test of time, with slight variations in different geographical contexts. The lack of value recognition, restrictions imposition, and resulting protection has led to the loss of memory of material and immaterial values. Restoring dignity has been the primary goal of those who have given substance and vitality to the theme of Modern Restoration, inheriting from the past the method that requires, in order to catalogue each work, the essential stages of knowledge and documentation, preliminary to conservation and enhancement. It is precisely in this scenario, after analysing the experiences of institutions, bodies and associations in the field of filing and cataloguing, that the needs brought about by the digital transition were taken on board; the aim is to define, within the PRIN 2022 DIMHENSION project, an innovative operative protocol that is economically, socially and technically sustainable, aimed at the computerised management of 20th century architectural heritage. The steps are the identification of the global description of the history of the building, translation of the entire body of data into information assets (H-BIR), and the possibility of consultation using parametric models (H-BIM). A Digital Register has therefore been designed, initially for an international sample of late 20th century façade systems, which goes well beyond their dynamic documentation, creating the conditions for a platform for consulting the complex of information, structured in an H-BIR archive interfaced with an H-BIM object library.