There have been several reported cases of severe acute respiratory syndrome (SARS-CoV-2) infection that were associated with an increased incidence of neurological manifestations, including Guillain–Barré syndrome (GBS). This review aims to present information on the reports of GBS associated with coronavirus disease 2019 (COVID-19) infection. Our review is retrospective work examining articles published from the 1 April 2020 to the 8 May 2021 in the English language. We used the diagnostic criteria and classification published by the National Institute of Neurological Disorders and Stroke and Brighton Collaboration. GBS is usually a postinfectious syndrome, but GBS in the COVID-19 pandemic also takes on a para-infectious profile. In the reports, the genetic factor has a role in developing GBS in some patients. In conclusion, the association between COVID-19 and GBS is not very clear. Still, one mechanism is strongly associated with COVID-19 and immune-mediated neurological complications, which is molecular mimicry between SARS-CoV-2 and human autoantigens.

Background: Thalassemia and hemoglobinopathies have significant complications on the children's health. Also, they have a higher cost for treatment. The prevalence of these diseases differs from one area to another in Saudi Arabia. Aims: To detect the different hemoglobin abnormality and their frequency in the premarital population in Makkah city. Methods: A cross-sectional study was conducted, which included 473 subjects who attended the premarital screening tests at the maternity and children Hospital laboratory and Heraa hospital. We were collected the data of the complete blood count, hemoglobin electrophoresis, and iron profile from the participants. The statistical analysis was performed by SPSS program version 20. Results: 74.8% of the participants were normal, 9.3% had iron deficiency anemia (IDA), 6.3% were suspected to be alpha thalassemia trait, 3.4% had sickle cell trait, 3% were polycythemia, 1.5% had hereditary persistence fetal hemoglobin (HPFH), 1.1% were IDA with thalassemia trait, 0.4% were beta thalassemia trait, 0.2% had hemoglobin E trait. Conclusion: thalassemia trait and hemoglobinopathies are present in the premarital population in Makkah city at a low prevalence. The highest frequency was for the alpha thalassemia trait, then sickle cell trait, then HPFH, then beta-thalassemia trait, and lastly, hemoglobin E trait. IDA is present at a high frequency. Education to the population is essential to decrease the prevalence of these disorders.

A 73-year-old man on chronic warfarin therapy presented to the emergency department with acute right thigh pain and swelling, without a history of trauma. Musculoskeletal point-of-care ultrasound (MSK-POCUS) rapidly identified an intramuscular hematoma with evidence of active hemorrhage. Subsequent computed tomography angiography (CTA) confirmed a sizable hematoma in the right vastus intermedius muscle and detected a small pseudoaneurysm. The patient was managed conservatively, with close monitoring yielding no further complications. This case demonstrates the diagnostic utility and efficiency of MSK-POCUS in the acute evaluation of musculoskeletal complaints, particularly in patients at risk for anticoagulant-induced bleeding. The report highlights the value of bedside ultrasound for prompt diagnosis, its advantages over other imaging modalities in emergency settings, and the importance of enhancing training for widespread POCUS implementation in clinical practice.