The process of platelet activation and blood coagulation is quite complex and not yet completely understood. Recently, a phenomenological meaningful model of blood coagulation and clot formation in flowing blood that extends existing models to integrate biochemical, physiological and rheological factors, has been developed. The aim of this paper is to present results from a computational study of a simplified version of this coupled fluid‐biochemistry model. A generalized Newtonian model with shear‐thinning viscosity has been adopted to describe the flow of blood. To simulate the biochemical changes and transport of various enzymes, proteins and platelets involved in the coagulation process, a set of coupled advection–diffusion–reaction equations is used. Three‐dimensional numerical simulations are carried out for the whole model in a straight vessel with circular cross‐section, using a finite volume semi‐discretization in space, on structured grids, and a multistage scheme for time integration. Clot formation and growth are investigated in the vicinity of an injured region of the vessel wall. These are preliminary results aimed at showing the validation of the model and of the numerical code.

This paper presents numerical results based on a macroscopic blood coagulation model coupled with a non-linear viscoelastic model for blood flow. The system of governing equations is solved using a central finite-volume scheme for space discretization and an explicit Runge-Kutta time-integration. An artificial compressibility method is used to resolve pressure and a non-linear TVD filter is applied for stabilization. A simple test case of flowing blood over a clotting surface in a straight 3D vessel is solved. This work presents a significant extension of the previous studies [10] and [9].

This paper is concerned with the numerical simulation of a thermodynamically compatible viscoelastic shear-thinning fluid model, particularly well suited to describe the rheological response of blood, under physiological conditions. Numerical simulations are performed in two idealized three-dimensional geometries, a stenosis and a curved vessel, to investigate the combined effects of flow inertia, viscosity and viscoelasticity in these geometries. The aim of this work is to provide new insights into the modeling and simulation of homogeneous rheological models for blood and a basis for further developments in modeling and prediction.