In this paper, we propose a multi-channel photonic crystal fiber sensor, which adopts dual-polarization and multiple materials to effectively reduce the mutual interference between channels and enhance the surface plasmon resonance, thus achieving simultaneous detection of a multi-channel with low interference. Four channels are polished around the cylindrical fiber, and then different metal films (gold or silver) and plasmonic materials (titanium dioxide, thallium pentoxide, or graphene) are added to the sensing area of each channel. All channels detect refractive indices in the range of 1.34 to 1.42. The sensing performance of the fiber optic sensor was numerically investigated using the full vector finite element method. After the optimization of structural parameters, the maximum wavelength sensitivity of channel-1, channel-2, channel-3, and channel-4 are 49,800 nm/RIU, 49,000 nm/RIU, 35,900 nm/RIU, and 36,800 nm/RIU, respectively. We have theoretically analyzed the sensor’s capabilities for partial bio-detection and simulated its detection capability with a wavelength sensitivity of 11,500 nm/RIU for normal red blood cells and 12,200 nm/RIU for MCF-7 cancerous cells. Our proposed sensor has a novel design, can detect multiple channels simultaneously, has strong anti-interference capability and high sensitivity, and has good sensing characteristics.

To achieve high performance and wide range detection, we propose an ultra-wide range high sensitivity plasmonic fiber optic sensor with a gold (Au) nanowire group array, which has both propagating surface plasmon resonance (PSPR) and local surface plasmon resonance (LSPR) sensing characteristics. The PSPR, LSPR, and PSPR+LSPR are presented as Au thin layers, Au spheres (or Au nanowires), and Au nanowire group arrays, respectively, and their respective properties are analyzed from theoretical, simulated, and numerical aspects. When detection is performed, the presence of both evanescent wave and electric field forces in the Au nanowire group array combines to significantly improve the sensor’s detection capability. Detection simulation analysis was performed using COMSOL Multiphysics software. The range of refractive indices that can be detected is 1.08 to 1.37 in the optical band from 1210 nm to 2140 nm. In the detection range, the maximum sensitivity of the detected wavelength is 13,000 nm/RIU. Our proposed sensor has a broad range, high sensitivity, and low refractive index detection, and has good research value and application prospects.