Metallic foams find their applicability in complex systems that operate under both real-life conditions (Earth living conditions) and extreme temperature conditions (low or high temperatures). In this paper, the main mechanical properties of closed-cell aluminum alloy (A356) foams under quasi-static compression loading conditions were determined. In order to investigate the compressive behavior, three orthogonal directions (X, Y, and Z) and three testing temperatures (−196, 25 and 250 °C) were considered. It has been observed that the temperature significantly influences the strength properties and energy absorption performances of the aluminum metallic foams AMFs. Moreover, it was found that microstructural characteristics, such as intrinsic defects (intracellular cavities, micro-pores and thin cell-walls) and structural anisotropy (shape, size and orientation of cells), play a decisive role in the mechanical behavior of AMFs. Moreover, the paper compares the relative percentage change (relative percentage increase and decrease) of the main normalized compressive properties (yield stress, plateau stress, densification stress and the energy absorption) of AMF samples, according to testing temperature and loading direction.