In this paper, we study the global dynamics of an susceptible, vaccinated, infectious and recovered epidemiological model with infection-age structure. Biologically, we assume that effective contacts between vaccinated individuals and infectious individuals are less than that between susceptible individuals and infectious individuals. Using Lyapunov functions, we show that the global stability of each equilibrium is completely determined by the basic reproduction number $\Re _0$ : if $\Re _0\leqslant 1,$ then the disease-free equilibrium is globally asymptotically stable; while if $\Re _0 > 1$ , then there exists a unique endemic equilibrium which is globally asymptotically stable.
In this paper, an Susceptible-Vaccines-Exposed-Infectious-Recovered model with continuous age-structure in the exposed and infectious classes is investigated. These two ages are assumed to have arbitrary distributions that are represented by age-specific rates leaving the exposed and the infectious classes. We investigate the global dynamics of this model in the sense of basic reproduction number via constructing Lyapunov functions. The asymptotic smoothness of solutions and uniform persistence of the system is shown from reformulating the system as a system of Volterra integral equations.
13 August 2021 in Journal of Dynamics and Differential Equations
A recent paper [F. Brauer, Z. Shuai and P. van den Driessche, Dynamics of an age-of-infection cholera model, Math. Biosci. Eng., 10, 2013, 1335--1349.] presented a model for the dynamics of cholera transmission. The model is incorporated with both the infection age of infectious individuals and biological age of pathogen in the environment. The basic reproduction number is proved to be a sharp threshold determining whether or not cholera dies out. The global stability for disease-free equilibrium and endemic equilibrium is proved by constructing suitable Lyapunov functionals. However, for the proof of the global stability of endemic equilibrium, we have to show first the relative compactness of the orbit generated by model in order to make use of the invariance principle. Furthermore, uniform persistence of system must be shown since the Lyapunov functional is possible to be infinite if$i(a, t)/i^* (a) =0$ on some age interval.In this note, we give a supplement to above paper with necessary mathematical arguments.