Fangdi Hu

As an important edible traditional Chinese medicine, Codonopsis pilosula has good immunomodulation effects. This study focuses on C. pilosula oligosaccharides (CPO), which are the sweetness components of C. pilosula. CPO were obtained through systematic separation and purification (the yield is 14.3%), and the effect of CPO on the immunological activities of immunocompromised mice induced by cyclophosphamide (CTX) was evaluated. The results showed that CPO could increase immune organ indices, phagocytic index and immunoglobulin contents, stimulate the proliferation of splenic lymphocytes (coordinating with ConA and LPS), enhance the earlap swelling of the DTH reaction, promote the production of NO and cytokines (IL-2 and IFN-γ) and upregulate the expression of the corresponding mRNA. In addition, CPO upregulated the protein expression of phosphorylated p38, phosphorylated ERK1/2 and phosphorylated JNK, which indicated that CPO might exert immunomodulatory effects through the MAPK signaling pathway. These findings indicated that CPO are important immunomodulatory components in C. pilosula and could be developed as immunomodulators in medicine or functional food areas.

1 December 2018 in International Journal of Biological Macromolecules

Journal Article

Cytotoxicity of two water-soluble polysaccharides from Codonopsis pilosula Nannf. var. modesta (Nannf.) L.T.Shen against human hepatocellular carcinoma HepG2 cells and its mechanism

Ruibin Bai

Wuyan Li

Yingdong Li

Ming Ma

Yanping Wang

Fangdi Hu

1 November 2017 in International Journal of Biological Macromolecules

Journal Article

Structural characterization of a pectic polysaccharide from Codonopsis pilosula and its immunomodulatory activities in vivo and in vitro

Pei Zhang

Linhai Hu

Ruibin Bai

Xiaoping Zheng

Yuling Ma

Fangdi Hu

1 September 2014 in Materials Science and Engineering: C

Journal Article

Electrochemically reduced graphene oxide-based electrochemical sensor for the sensitive determination of ferulic acid in A. sinensis and biological samples

Linjie Liu

Yuqiang Gou

Xia Gao

Pei Zhang

Wenxia Chen

Yingdong Li

1 July 2019 in Biosensors and Bioelectronics

Journal Article

Porous graphene-black phosphorus nanocomposite modified electrode for detection of leptin

Jinying Cai

Xiaodan Gou

Bolu Sun

Wuyan Li

Dai Li

Yingdong Li

About Me

Fangdi Hu: doctor, professor, doctoral supervisor. She is an expert who enjoys the special allowance of the State Council, a leading talent of Gansu Province, a "Flying Scholar" lecturer of Gansu Province, a model woman scientist at Lanzhou University, and an outstanding talent of "Guohua". She has led and completed more than 30 research projects. Representative scientific research projects: Gansu Province major project "Long source of food and medicine substances fresh storage key technology research and application"; National Natural Science Foundation of China project based on "flexible electrode platform depression marker electrochemical immunosensor construction and application"; national Key R&D Program "Modernization of Traditional Chinese Medicine"; Special Project "Key Technology Research on Party Ginseng Industry and Development of Health Products"; Gansu Province Innovation Guidance Special Fund Project "Innovative Research on Comprehensive Utilization of Gansu Special Drug Resources Platform"; Gansu Province Science and Technology Major Project "Gansu Province local customary medicinal herb quality standard improvement and industrialization application", etc.

Fangdi Hu

Fangdi Hu

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