Health isn’t a destination; it’s a thrilling, infuriating, and totally worth-it journey. My motivation as a physician and as a researcher is healthy living, which is complex and multifactorial and baffles modern medicine at nearly every turn. While there have been advances, much about healthy living remains unknown and the subject of intense debate. Physical activity is a lifestyle and behavioral factor that has been suggested to play a role in the etiology, prevention and rehabilitation of many chronic diseases. I wish to combine epidemiological, experimental and clinical expertise to an integrated approach in hope to find identifying the key cellular and molecular mechanisms underlying the beneficial effects of physical exercise on lifestyle-related disease.