The automatic detection of diabetic retinopathy is of vital importance, as it is the main cause of irreversible vision loss in the working-age population in the developed world. The early detection of diabetic retinopathy occurrence can be very helpful for clinical treatment; although several different feature extraction approaches have been proposed, the classification task for retinal images is still tedious even for those trained clinicians. Recently, deep convolutional neural networks have manifested superior performance in image classification compared to previous handcrafted feature-based image classification methods. Thus, in this paper, we explored the use of deep convolutional neural network methodology for the automatic classification of diabetic retinopathy using color fundus image, and obtained an accuracy of 94.5% on our dataset, outperforming the results obtained by using classical approaches.

The classification of underwater acoustic signals has garnered a great deal of attention in recent years due to its potential applications in military and civilian contexts. While deep neural networks have emerged as the preferred method for this task, the representation of the signals plays a crucial role in determining the performance of the classification. However, the representation of underwater acoustic signals remains an under-explored area. In addition, the annotation of large-scale datasets for the training of deep networks is a challenging and expensive task. To tackle these challenges, we propose a novel self-supervised representation learning method for underwater acoustic signal classification. Our approach consists of two stages: a pretext learning stage using unlabeled data and a downstream fine-tuning stage using a small amount of labeled data. The pretext learning stage involves randomly masking the log Mel spectrogram and reconstructing the masked part using the Swin Transformer architecture. This allows us to learn a general representation of the acoustic signal. Our method achieves a classification accuracy of 80.22% on the DeepShip dataset, outperforming or matching previous competitive methods. Furthermore, our classification method demonstrates good performance in low signal-to-noise ratio or few-shot settings.

Agents significantly enhance the capabilities of standalone Large Language Models (LLMs) by perceiving environments, making decisions, and executing actions. However, LLM agents still face challenges in tasks that require multiple decision-making steps. Estimating the value of actions in specific tasks is difficult when intermediate actions are neither appropriately rewarded nor penalized. In this paper, we propose leveraging a task-relevant Q-value model to guide action selection. Specifically, we first collect decision-making trajectories annotated with step-level Q values via Monte Carlo Tree Search (MCTS) and construct preference data. We then use another LLM to fit these preferences through step-level Direct Policy Optimization (DPO), which serves as the Q-value model. During inference, at each decision-making step, LLM agents select the action with the highest Q value before interacting with the environment. We apply our method to various open-source and API-based LLM agents, demonstrating that Q-value models significantly improve their performance. Notably, the performance of the agent built with Phi-3-mini-4k-instruct improved by 103% on WebShop and 75% on HotPotQA when enhanced with Q-value models, even surpassing GPT-4o-mini. Additionally, Q-value models offer several advantages, such as generalization to different LLM agents and seamless integration with existing prompting strategies.

Recently, deep learning has achieved state-of-the-art performance in more aspects than traditional shallow architecture-based machine-learning methods. However, in order to achieve higher accuracy, it is usually necessary to extend the network depth or ensemble the results of different neural networks. Increasing network depth or ensembling different networks increases the demand for memory resources and computing resources. This leads to difficulties in deploying depth-learning models in resource-constrained scenarios such as drones, mobile phones, and autonomous driving. Improving network performance without expanding the network scale has become a hot topic for research. In this paper, we propose a cross-architecture online-distillation approach to solve this problem by transmitting supplementary information on different networks. We use the ensemble method to aggregate networks of different structures, thus forming better teachers than traditional distillation methods. In addition, discontinuous distillation with progressively enhanced constraints is used to replace fixed distillation in order to reduce loss of information diversity in the distillation process. Our training method improves the distillation effect and achieves strong network-performance improvement. We used some popular models to validate the results. On the CIFAR100 dataset, AlexNet’s accuracy was improved by 5.94%, VGG by 2.88%, ResNet by 5.07%, and DenseNet by 1.28%. Extensive experiments were conducted to demonstrate the effectiveness of the proposed method. On the CIFAR10, CIFAR100, and ImageNet datasets, we observed significant improvements over traditional knowledge distillation.

Motivation: Generative models have demonstrated considerable promise in de novo protein design. Traditional approaches typically focus on either sequence or structure in isolation, limiting the capacity to explore the intricate sequence–structure landscape and achieve optimal designs. However, joint protein sequence and structure co-design remains a largely underexplored challenge. Results: We present CoFlow, a discrete model for protein co-design from scratch or given constraints. CoFlow employs a joint discrete flow and integrates a multi-modal protein masked language model to facilitate co-design in the discrete space. Comprehensive experiments demonstrate that CoFlow outperforms previous design methods across multiple evaluation metrics. Notably, CoFlow achieves a consistency approximately eight times higher than that of ESM3 in unconditional generation. Moreover, CoFlow exhibits competitive performance in conditional generation tasks, including motif-scaffolding, protein folding, and inverse folding. Availability and implementation: The source code of CoFlow, including data preprocessing and model, is available at https://github.com/LtECoD/CoFlow and https://zenodo.org/records/14842367. (DOI: 10.5281/zenodo.14842367).