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Dr. Xiao Duan
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Representative Publications
View All Publications19 December 2016 in Biomaterials Science
Journal Article
In the cutting-edge field of cancer therapy, noninvasive photothermal therapy (PTT) has received great attention because it is considered to overcome the drawbacks of conventional surgery, radiotherapy and chemotherapy of severe body injuries and side effects on the immune system.
1 July 2018 in Carbohydrate Polymers
Journal Article
LQLiwei Qian
Liwei QianDLDan Lei
Dan Lei
XDXiao Duan
Xiao DuanSZSufeng Zhang
Sufeng ZhangWSWenqi Song
Wenqi SongRTRuihua Tang
Ruihua Tang
+1
30 November 2017 in Journal of Materials Chemistry B
Journal Article
We present a novel glutathione-responsive amphiphilic drug self-delivery (DSD) micelle with one-pot synthesis to synergistically address the problems of controlled drug release, degradability, drug tracing and in vivo accumulated toxicity. The anticancer drug doxorubicin (DOX), disulfide-based diacrylate (DSDA) and amino-polyethylene glycol monomethyl ether were linked by Michael addition in one-pot synthesis. The accumulative release rate of DOX analogues with drug activity from the micelles was 67.9% under pH 7.4 and GSH = 1 mg mL−1 conditions after 72 h. The cell uptake experiment showed that the micelles of DOX–DSDA–PEG were indeed taken up by A549 cells and distributed to cell nuclei. The in vitro cell viability of A549 cells was evaluated by CCK-8 and Muse Annexin V & Dead Cell Kit. The results illustrated that the completely biodegradable micelles with glutathione-responsive bonds in the backbone are an effective drug self-delivery system for tumor therapy in the future.
23 November 2016 in ACS Biomaterials Science & Engineering
Journal Article
25 March 2014 in Journal of Polymer Research
Journal Article
YQYoubei Qiao
Youbei Qiao
XDXiao Duan
Xiao DuanLFLi Fan
Li Fan
WLWei Li
Wei Li
HWHong Wu
Hong WuYWYukun Wang
Yukun Wang24 March 2018 in Chemistry – An Asian Journal
Journal Article
XDXiao Duan
Xiao DuanJCJianxin Chen
Jianxin ChenYWYalan Wu
Yalan Wu
Si WuDSDongyan Shao
Dongyan ShaoJKJie Kong
Jie KongAbout Me
Xiao Duan, Ph.D.
Dr. Xiao Duan is the vice dean of the School of Pharmacy at the Changzhi Medical College of China with a research focus on drug delivery systems used for cancer therapy. He received his bachelor's degree at Changzhi Medical College, his master's degree at Fourth Military Medical University, and his doctorate degree at Northwestern Polytechnical University. He served as an academic scholar at University College Cork sponsored by the China Scholarship Council. To date, he has published many high-quality papers on drug delivery and the biomedical application field and has led research projects supported by Shanxi province and the National Natural Science Foundation of China. His published papers in journals including Nano Today, Carbohydrate Polymers, Materials Today Nano, International Journal of Biological Macromolecules, Journal of Controlled Release, Acta Biomaterialia, Journal of Materials Chemistry B, ACS Biomaterials Science & Engineering, ACS Applied Materials & Interfaces, Journal of the Taiwan Institute of Chemical Engineers, etc.