Boron compounds now have many applications in a number of fields, including Medicinal Chemistry. Although the uses of boron compounds in pharmacological science have been recognized several decades ago, surprisingly few are found in pharmaceutical drugs. The boron-containing compounds epitomize a new class for medicinal chemists to use in their drug designs. Carboranes are a class of organometallic compounds containing carbon (C), boron (B), and hydrogen (H) and are the most widely studied boron compounds in medicinal chemistry. Additionally, other boron-based compounds are of great interest, such as dodecaborate anions, metallacarboranes and metallaboranes. The boron neutron capture therapy (BNCT) has been utilized for cancer treatment from last decade, where chemotherapy and radiation have their own shortcomings. However, the improvement in the already existing (BPA and/or BSH) localized delivery agents or new tumor-targeted compounds are required before realizing the full clinical potential of BNCT. The work outlined in this short review addresses the advancements in boron containing compounds. Here, we have focused on the possible clinical implications of the new and improved boron-based biologically active compounds for BNCT that are reported to have in vivo and/or in vitro efficacy.

Different chitosan-titanium oxide (CS-TiO₂-x, with x = TiO₂ loadings of 1, 5, 10,15 and 20 wt%) nanocomposite fibers were prepared and kept separately in each salt solution of CuSO₄, CoNO₃, AgNO₃ and NiSO₄ to adsorb Cu²⁺, Co²⁺, Ag⁺, and Ni⁺ ions, respectively. The metal ions loaded onto CS-TiO₂ fibers were reduced to their respective zero-valent metal nanoparticles (ZV-MNPs) like Cu⁰, Co⁰, Ag⁰ and Ni⁰ by treating with NaBH₄. The CS-TiO₂ fibers templated with various ZV-MNPs were characterized and investigated for their catalytic efficiency. Among all prepared ZV-MNPs, Cu⁰ nanoparticles templated on CS-TiO₂-15 fibers exhibited high catalytic efficiency for the reduction of dyes (methyl orange (MO), congo red (CR), methylene blue (MB) and acridine orange (AO)) and nitrophenols (4-nitrohphenol (4-NP), 2-nitrophenol (2-NP), 3-nitrophenol (3-NP) and 2,6-dinitrophenol (2,6-DNP)). Besides the good catalytic activities of Cu/CS-TiO₂-15 fibers, it could be easily recovered by simply pulling the fiber from the reaction medium.

A simple, economically viable and fast method has been utilized for the preparation of highly active metal nanoparticles (MNPs) in coating layer of chitosan (CH) over cellulose microfibers of cotton cloth (CC). 2 wt% of CH solution was used for the coating of CC strips (CC-CH), and were kept in aqueous solutions of metal salts to adsorb metal ions. The CC-CH templated with metal ions were then treated with aqueous solution of NaBH₄ to reduce the metal ions into zero-valent metal nanoparticles (M⁰). The CC-CH strips loaded with M⁰ were characterized by XRD, XPS, ATR-FTIR, FE-SEM and TGA, which indicates the successful synthesis of MNPs by this method. The M⁰/CC-CH strips were used as an efficient catalyst for the model reduction reaction of nitrophenol and toxic organic dyes. Among all the prepaped samples, Fe/CC-CH showed good catalytic activity for 4-NP and Rh-B dye reduction in the presence of NaBH₄ with rate constants of 0.2937 min⁻¹ and 0.3804 min⁻¹, respectively. Moreover Fe/CC-CH has good catalytic reduction ability for MO and MB having rate constants equal to 0.1698 and 0.2802 min⁻¹, respectively. Beside the good catalytic ability, it could be easily recoverable as compared to other available techniques. The recovery was completed by simply pulling the strip from the reaction matrix after completion of the reaction and can be used several times.