Recent scientific publications suggest that human longevity records stopped increasing. Our finding that the mortality of centenarians has not decreased noticeably in recent decades (despite a significant mortality decline in younger age groups) is consistent with this suggestion. However, there is no convincing evidence that we have reached the limit of human life span. The future of human longevity is not fixed and will depend on human efforts to extend life span.

We review the progression of aging as a sequential development of multiple syndromes analogous to other diseases. This generalized approach may allow practicing physicians to consider the signs of aging as manifestations of a poly-syndrome disease and facilitate prevention, diagnosis and treatment of common aging-related dysfunctions.

There were analyzed psychogygienic problems of the impact of the informational environment on children and adolescents. Their scope and controversy are shown. There are considered such problems related with virtual reality as clip thinking, consciousness manipulating, network self-identification, Internet dependence. The possibility of the creation of a knowledge-based society is set against a change of the development of consumer society. As a basic method for adaptation of children and adolescents to permanently informational environment there is proposed the aim-oriented development of cognitive and creative abilities and also skills ofknowledge extraction form information. The delivery of psychohygienic technologies for the work with information will allow to withstand against a destroying effect of mass culture and to use resourcefully opportunities of non-linear virtual environment.

Additionally to the assessment of the external environment for the evaluation of the hygienic welfare of the population it is ultimately important to assess the health status, the index of which should be monitored as early as possible. Prenosological changes are the most early and common, they reflect the cumulative impact of adverse effects of the external environment of very different nature and their evaluation on human health is the most important. For a more accurate and standardized assessment of such effects we have developed a number of computer systems, allowing to estimate both physical and mental health and performance, and also biological age of a person. Our programs involve individual records of customer data, both physical and mental activity in everyday life, the degree of stress tolerance, the presence of occupational hazards, exercise, food tastes etc. Design of programs includes standardized windows: data entry, tabular and graphical output of results in comparison with age-related standards, output of the text and conclusion the database with the ability to view them and compare the results of several visits. Database programs have similar form and can be presented in a ExCel format for the statistical treatment. Overall, we have developed a computer system for the assessment of physical and mental health, working capability and biological age, that is a powerful tool for the accurate and standardized evaluation of the external adverse environmental influences on the health and general well-being, provides ways to an early preclinical diagnosis and environmental well-being and can be widely used in sanitary and hygienic monitoring of the health status of the population.

There are two well-known but opposing concepts of the reason for aging. The first supposes that senescence is programmed similarly to the genetic program of development from a zygote up to a mature organism. Genetically determined senile wasting is thought to be associated with the necessity to renovate the population to ensure its adaptation and survival. According to the concept of the stochastic aging (due to accumulation of occasional error and damage), there is no built-in program of aging. There is only a program of development up to the state of maturity, and then the organism should be able to maintain itself limitlessly. However, although the efficiency of repair systems is assumed to be rather high, it is less than 100%. Just this has to result in aging because of accumulation of various errors. We have continued and developed another approach that considers both programmed and stochastic concepts to be incorrect. Aging is a simple deprivation syndrome driven by preventable and even reversible drifts of control systems set points because of an inappropriate “organism-environment” interaction.

The widespread formation of unfavorable environmental, the swiftness of modern life with large information and psycho-emotional loads and extremely natural and climatic cataclysms, as well as harmful addictions and wrong way of life of modern human, lead to the development of stress and disruption of the mechanisms of adaptation of the human body and its accelerated wear. This stimulates the development of research on the creation of new methods of integrated assessment of health and quantitative assessment of the aging processes of the body systems and the whole body, as well as the possibilities of new methods of risk assessment of climatic and environmentally related pathological and age-related diseases. The aim of the work was to consider the methodology of quantitative assessment of individual health and the rate of aging of the human body on the basis of the system index of Biological age (BA); description of its essence and structure, requirements for tests - biomarkers of aging used as the index of BA, definition of possibilities and scope of application of the BA method in modern practice of Biomedicine. The use of modern methods of scientific analysis - a systematic approach to the analysis of the processes of human aging and determine its quantitative side - the value of BA, allows a reasonable approach to the choice of the number of BM, to take into account their information content and precision, and the cost of diagnostics and availability for different users, to take into account the specific objectives of the researcher. The use of the index-partial BA allows individual approaching the choice of biomarkers and create personalized panels for the definition of BA programs for the prevention of aging in personalized preventive medicine. The complexity of the content and calculation of indices of BA requires automation and the use of methods of modern computer science and computer calculations and programs. For this purpose, we have created special computer software for diagnosing aging by calculating the BA indices with the possibility of choosing BM and automatic calculation of indicators and conclusions.