Metabolic syndrome (MetS) is closely associated with adverse cardiometabolic outcomes. The objective of this study was to identify practical methods that could enable the effective identification of MetS based on anthropometric indices. The basis of our study involved retrospective database obtained from routine medical prophylactic examinations. This was a cross-sectional study on the health status of male workers employed in hazardous working conditions at industrial enterprises in the Ural region conducted in 2019. A total of 347 male workers employed under hazardous working conditions were investigated. The presence of MetS was established by a healthcare professional in accordance with the guidelines of the International Diabetes Federation (IDF). Simple linear regression was used to evaluate the associations between anthropometric indices and MetS incidence. Logistic regression was used to determine the odds ratios of MetS in relation to increases in anthropometric indices. ROC curves were calculated to compare the ability of each anthropometric index to predict MetS and to determine the diagnostic thresholds of the indicators considered. According to the IDF criteria, 36.3% of the workers had MetS. A direct relationship was found between the individual components of MetS and the anthropometric indices studied. The highest OR was shown by the Body Roundness Index (BRI) of 2.235 (95% CI 1.796–2.781). For different age quartiles, the optimal cut-off values for predicting MetS were as follows: BRI, 4.1–4.4 r.u.; body shape index (ABSI), 0.080–0.083 m^11/6 kg^−2/3; and lipid accumulation product (LAP), 49.7–70.5 cm mmol/l. The most significant associations with MetS were observed where the values were greater than these cut-off points (Se = 97.4%). The results of this study demonstrated the rapid use of new anthropometric indicators, which have shown good predictive ability and are quite easy to use.

The aim of this study was to determine the effect of smoking on BMI in male adolescents and explore the relationship between smoking status and diet. Methods: A cross-sectional epidemiological study into the health and diet of adolescents was carried out based on a representative sample of 375 vocational school male students aged 16–17 in the city of Chelyabinsk (Russian Federation). The students and their parents filled out verified questionnaires on their socioeconomic status, diet, and smoking status. Students’ height and body weight were measured. A comparative analysis of diets was performed between groups of smokers and non-smokers (149 and 226 individuals, respectively), and the relationship between smoking, body mass index, and actual diet was estimated. The methods used included descriptive statistics, Student’s t-test, Mann–Whitney U test, comparison of proportions, and moving average. Results: Non-smoking adolescent boys tended to have excess body mass compared with smokers (19.0% and 12.1%, respectively). Smokers (adolescent boys) consumed less meat, cereals, beans, and cheeses and more sweet beverages, added sugar, coffee, and alcohol. The bulk of the smokers’ diet was composed of carbohydrates (p = 0.026) and, to a lesser extent, proteins (p = 0.006). Conclusions: Significant differences were discovered in the diet between smokers and non-smokers (among adolescent boys), and smoking was associated with several indicators of unhealthy diet patterns. This is an important conclusion for developing a future program that could additionally protect at-risk groups of adolescents.

Introduction: It is important to assess health impact of the entire set of heterogeneous risk factors and identify the key ones in order to develop personalized measures for prevention of non-occupational diseases in workers. Objective: To establish the major risk factors for circulatory and musculoskeletal disorders in employees of a metallurgical enterprise. Materials and methods: We used anonymized data from a special assessment of working conditions and production control of the forging departments of the forging-rod and forging-press shops of a metallurgical enterprise producing titanium alloys for the years 2016–2020. To determine the presence of personal biological and behavioral risk factors for diseases of the circulatory and musculoskeletal systems, we examined anonymized data of the periodic medical check-up conducted in 2020 of 146 male blacksmiths working with hammers and presses. The mean age of the workers was 35.9 ± 8.8 years (range: 21 to 57 years) and their mean length of current employment was 18.9 ± 9.7 years (range: 2 to 41 years). The method of simple and multiple logistic regression was used to build models for predicting the likelihood of a disease; odds ratios were calculated with a 95 % confidence interval. The quality of the models was assessed using the maximum likelihood estimation. Results: We determined the factors allowing prediction of the disease likelihood. The prevalence of circulatory diseases correlated with age, length of employment, and the body mass index, whole-body and hand-arm vibration, noise exposure, high ambient temperature, thermal radiation, and heavy physical work. The prevalence of musculoskeletal diseases, in its turn, had a somewhat weaker statistically significant association with the same risk factors. Models predicting the likelihood of circulatory and musculoskeletal diseases have been built. The best predictive model for circulatory diseases included the combined effect of the body mass index and heavy physical work while that for musculoskeletal disorders – of the body mass index and hand-arm vibration. Conclusion: Multiple logistic regression used to analyze statistical relationships between work-related risk factors and disease prevalence in employees in specific occupations allowed identification of the leading factors contributing the most to the disease development and can be recommended for solving practical problems in occupational medicine.

Introduction. Cardiovascular diseases (CVDs) are the leading cause of death in working-age population, including mortality occurring through occupational fatalities. The core principle in fighting CVDs is having special consideration for individuals with a high risk of its development. In order to identify those individuals, the SCORE (Systematic Coronary Risk Evaluation) system is advised. The realizations (i.e. the effects of exposure) with respect to the same risk factors may vary across individuals. Therefore, it is of urging importance to conduct an assessment of the integral cardiovascular risk estimates that are informative of coming-to-an-effect long-term exposures to adverse factors and helpful in identifying changes at early reversible stages of CVD. Material and methods. A cross-sectional study included 108 male workers aged 27-63 years, without apparent health disorders who been working in unsafe conditions over from 4 to 40 years, employed as occupational staff (converter furnace operators, charge workers, burners, smelters) in copper production enterprises of the Sverdlovsk region. Clinical examination and laboratory tests were conducted at the Yekaterinburg Medical Research Center in 2017-2018. The evaluated indices included: total cholesterol (TC), glucose, Pb and Cu level in blood. A 3D-sphygmography with CAVI assessment and aa. carotides ultrasound with intima-media thickness (IMT) assessment were performed. Cardiovascular risk (CVR) was evaluated according to the SCORE assessment. Results. The following CVR factors were identified: smoking (72.2%), obesity of various classes (33.3%), TC > 4.9 mmol/l (57.9%), high fasting glucose (73.9%) and arterial hypertension stages 1-2 (40.7%). An arterial vessel stiffness increase by CAVI (>8.0) was found in 28.7% of subjects. Associations were found between CAVI index and (i) total CVR level as evaluated by SCORE (p=0.00105), (ii) blood Cu level (r=0.33). Therefore, further research is needed.

Aim. To identify the molecular genetic determinants of stress urinary incontinence (UI) in women. Materials and methods. A comparative study involving 120 women was conducted. Group 1 (main group) included 80 women with UI. Group 2 (comparison group) included 40 women without UI. Statistic data processing was performed using the Excel software package, SPP Statistics 22.0, Statistica for Windows 10 (TIBCO Software Inc., Palo Alto, CA, USA). The mean and standard deviation were reported for quantitative variables with a normal distribution. The statistical hypotheses on the absence of intergroup differences for quantitative variables with normal distribution were verified using Student's test. The absolute and relative values (in percent) were reported for qualitative variables. The chi-square test was used to verify the statistical hypotheses. Results. Molecular genetic predictors of UI in women are the carriage of polymorphisms of the estrogen receptor gene ESR1:-351_G and the type I collagen gene COL1A1:1546_T. These polymorphisms can be considered as genotypes of "risk" since their carriage is associated with an increased risk of UI. Conclusion. Genetically determined disorders of the estrogen receptor function and type I collagen synthesis can be one of the essential mechanisms of stress incontinence occurrence. Studying molecular genetic determinants of stress incontinence can provide a deeper understanding of its pathogenetic mechanisms and develop a personalized approach to surgical correction.