Dieckol [C₃₆H₂₂O₁₈], is a naturally occurring phlorotannin found in some brown algal species. Dieckol is gaining more attention in the scientific community for its potential biological activities. It has been exhibited a broad spectrum of therapeutic functions including anti-bacterial, anti-cancer, anti-oxidant, anti-aging, anti-diabetic, neuroprotective, and other medicinal applications. Distinct emphasis has been given to extraction, purification, and biomedical applications of dieckol. This critical review comprises of in vitro, in vivo, and in silico biological properties of dieckol. An attempt has been made to evaluate the effectiveness, therapeutical application, and mechanism of dieckol against various diseases. The pharmacological significance, current status and the dosage of multifunctional dieckol and its mechanisms have been discussed in this review. Dieckol plays an important role in apoptosis induction via inhibiting the PI3K, AKT, mTOR and FAK signaling molecules. Dieckol remarkably inhibited the lipid accumulation in high fat diet induced animal models. Dieckol, a multifaceted compound will be beneficial in attenuating the action of various diseases and it could be a potential pharmaceutical and nutraceutical compound. Therefore, the combined effects of dieckol with existing drugs and natural compounds will be studied in future to optimize its benefits. Besides limited information on the toxicological action and dosage administration of dieckol on the human was reported to date. Overall, dieckol is a prospective health-promoting compound for the development of a novel drug against numerous diseases.

Aquaculture is one of the primary food-producing sectors in the world that ensures human nourishment. However, aqua farmers are facing serious problems due to disease outbreaks and development of antimicrobial resistance. Until now, chemical or antibiotic based strategies have been applied to control disease related concern in aquaculture. Frequent usage of antibiotics in feed or usage of disinfectant to overcome the disease may end up with negative impacts to the environment and human. Utilization of plant derived polysaccharides has been drastically increased due to their effective roles and could serve as a best replacement for chemical agents and antibiotics. In addition, plant derived compounds and plant extracts were utilized to improve the immunity, intestinal health and growth performance of aquaculturable organisms. In addition, large number of plant-based polysaccharides was utilized as immunostimulants in aquaculture. Hence, this review aims to highlight the multifunctional properties of plant-based polysaccharides in aquaculture. Moreover, advantages and different concentration of plant polysaccharides as a feed additive in aquaculture sector have been discussed herein.