An organogel, a viscoelastic system, can be regarded as a semi-solid preparation which has an immobilized external apolar phase. The apolar phase is immobilized within spaces of the three-dimension...
1 March 2015 in Journal of the Mechanical Behavior of Biomedical Materials
Over the last two decades, organogels have found tremendous use in the pharmaceutical, food, and cosmetics industries with notable developments as drug delivery matrices and trans and saturated fat replacers in processed foods. The functionality of organogels benefits from their ease of preparation, cost effectiveness, and ability to contain both hydrophilic and lipophilic constituents. This review provides thorough insight into different organogelators, their mechanisms of organogel formation, various characterization techniques and their biocompatibility when administered in vivo. Finally, a special treatise is given on the applications of organogels as controlled drug delivery vehicles for topical, dermal/transdermal, parenteral, oral, and nasal routes. In situ forming organogels and their potential for tailored release of incorporated active ingredients are also discussed.
A large women population of the world is suffering from a vaginal infection commonly known as bacterial vaginosis. The disease is associated with the decrease in the lactobacilli count in the vagina. Till date, there is a lack of full proof treatment modalities for the cure of the disease. The treatment includes the use of antimicrobials and/or acidifying agents and probiotics, either separately or in combination. This note discusses about the etiology and the various present-day modalities of treatment of bacterial vaginosis.