Prof. Michele De Luca carries out scientific research and teaching activities in the scientific-disciplinary field of Medicinal Chemistry at the Department of Pharmacy and Health and Nutrition Sciences of the University of Calabria, in close collaboration with several national and international research groups. He has participated as an organizer and speaker at various national and international conferences and on the editorial board of several scientific journals. He has been in charge of scientific research projects entrusted to him by public and private institutions, as well as various research assignments abroad. The research activity focuses on the development and application of artificial intelligence methods to complex matrices in the pharmaceutical and food fields. Chemometric modeling is performed to analyze large data matrices from experimental measurements in order to predict features and classify unknown drug and food samples. Another aim of the research work is the study of photolabile drugs and the design of photostabilization systems; the processing of spectroscopic and chromatographic data using multivariate curve resolution techniques, quantitative structure–property relationships (QSPR), and quantitative structure–activity relationship (QSAR) approaches. Since 2022, he is an Associate Professor of Medicinal Chemistry at the DFSSN, University of Calabria.