Estrogens (ER) have a protective role against colorectal carcinoma (CRC). Reduction of death from CRC has been observed in women (30%) as compared to men (7%) in particular with the users of oral contraception and in those

Lumbar region is the mobile part of the vertebral column which is a weight bearing region. Unfortunately, the available data detecting the lumbar spine degenerative changes by MRI are still limited, particularly in Egypt. The present study aimed to the examination of possible age related changes in the lumbar spine in Egyptian people detected by MRI. Mid sagittal MRI scan were obtained from eighty symptomless persons (30 females 37.5 % and 50 males 62.5% of cases) between 25- 70 years of age. They were divided into two groups ; first group forty cases, 25-40 years (21 males & 19 females) and the second group forty cases , 41-70 years (29 males & 11 females). From all samples, there were 38 normal (47.5%) and the abnormal cases were 42 (52.5 %). It was found collectively that the abnormalities were more in males than females and that was supplemented by x²- test (4.83) and p value (0.028). The following diseases were seen ; Subchondral sclerosis, osteophytes, disc degeneration , subchondral multiple small cysts, disc prolapse and spondolysis with variations in ages and sexes. In conclusuion it was found that, the lumbar region affected early by the age and more affected in males than in females