Tissue equivalent materials (TEM) are frequently used in research as a means to determine the delivered dose to patients undergoing various therapeutic procedures. They are used in routine quality assurance and quality control procedures in diagnostic and therapeutic physics. However, very few materials that are tissue equivalent have been developed for use in research at the low photon energies involved in diagnosis radiology. The objective of this study is to describe a series of TEMs designed to radiographically imitate human tissue at diagnostic photon energies. TEMs for adipose, cortical bone, fat, lung, and muscle tissues were investigated in terms of energy absorption and exposure buildup factors for photon energy range 15–150 keV and for penetration depths up to 40 mean free path. BUF was computed based on GP-fitting method. Moreover, we also compared some radiological properties, including the total attenuation and the energy-absorption attenuation, the effective atomic number, and the CT number at 30, 100, and 120 kVp. We found that SB3, Glycerol trioleate, and MS15 perfectly mimic cortical bone, fat, and muscle tissues, respectively. Additionally, AP6 and Stracey latex are good TEM for adipose and lung tissues, respectively. The results of this work should be useful in radiation diagnosis and dosimetry applications for the large physician researcher community.