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The use of weak and inexpensive bases has recently opened promising perspectives towards the simpler and more sustainable synthesis of Au(I)-aryl complexes with valuable applications in catalysis, medicinal chemistry, and materials science. In recent years, continuous manufacturing has shown to be a reliable partner in establishing sustainable and controlled process scalability. Herein, the first continuous flow synthesis of a range of Au(I)-aryl starting from widely available boronic acids and various [Au(NHC)Cl] (NHC=N-heterocyclic carbene) complexes in unprecedentedly short reaction times and high yields is reported. Successful synthesis of previously non- or poorly accessible complexes exposed fascinating reactivity patterns. Via a gram-scale synthesis, convenient process scalability of the developed protocol was showcased.
Steven Patrick Nolan; Thibault Cauwenbergh; Nikolaos V. Tzouras; Thomas Scattolin; Subhrajyoti Bhandary; Andreas Simoens; Dr. Kristof Van Hecke; Dr. Christian V. Stevens. Continuous Flow Synthesis of [Au(NHC)(Aryl)] (NHC = N‐heterocyclic carbene) Complexes. Chemistry – A European Journal 2021, 1 .
AMA StyleSteven Patrick Nolan, Thibault Cauwenbergh, Nikolaos V. Tzouras, Thomas Scattolin, Subhrajyoti Bhandary, Andreas Simoens, Dr. Kristof Van Hecke, Dr. Christian V. Stevens. Continuous Flow Synthesis of [Au(NHC)(Aryl)] (NHC = N‐heterocyclic carbene) Complexes. Chemistry – A European Journal. 2021; ():1.
Chicago/Turabian StyleSteven Patrick Nolan; Thibault Cauwenbergh; Nikolaos V. Tzouras; Thomas Scattolin; Subhrajyoti Bhandary; Andreas Simoens; Dr. Kristof Van Hecke; Dr. Christian V. Stevens. 2021. "Continuous Flow Synthesis of [Au(NHC)(Aryl)] (NHC = N‐heterocyclic carbene) Complexes." Chemistry – A European Journal , no. : 1.
Roots are composed of different root types and, in the dicotyledonous Arabidopsis, typically consist of a primary root that branches into lateral roots. Adventitious roots emerge from non-root tissue and are formed upon wounding or other types of abiotic stress. Here, we investigated adventitious root (AR) formation in Arabidopsis hypocotyls under conditions of altered abscisic acid (ABA) signaling. Exogenously applied ABA suppressed AR formation at 0.25 µM or higher doses. AR formation was less sensitive to the synthetic ABA analog pyrabactin (PB). However, PB was a more potent inhibitor at concentrations above 1 µM, suggesting that it was more selective in triggering a root inhibition response. Analysis of a series of phosphonamide and phosphonate pyrabactin analogs suggested that adventitious root formation and lateral root branching are differentially regulated by ABA signaling. ABA biosynthesis and signaling mutants affirmed a general inhibitory role of ABA and point to PYL1 and PYL2 as candidate ABA receptors that regulate AR inhibition.
Yinwei Zeng; Inge Verstraeten; Hoang Trinh; Thomas Heugebaert; Christian Stevens; Irene Garcia-Maquilon; Pedro Rodriguez; Steffen Vanneste; Danny Geelen. Arabidopsis Hypocotyl Adventitious Root Formation Is Suppressed by ABA Signaling. Genes 2021, 12, 1141 .
AMA StyleYinwei Zeng, Inge Verstraeten, Hoang Trinh, Thomas Heugebaert, Christian Stevens, Irene Garcia-Maquilon, Pedro Rodriguez, Steffen Vanneste, Danny Geelen. Arabidopsis Hypocotyl Adventitious Root Formation Is Suppressed by ABA Signaling. Genes. 2021; 12 (8):1141.
Chicago/Turabian StyleYinwei Zeng; Inge Verstraeten; Hoang Trinh; Thomas Heugebaert; Christian Stevens; Irene Garcia-Maquilon; Pedro Rodriguez; Steffen Vanneste; Danny Geelen. 2021. "Arabidopsis Hypocotyl Adventitious Root Formation Is Suppressed by ABA Signaling." Genes 12, no. 8: 1141.
Often, different types of contaminants in wastewater are suspected of adversely affecting the treatment efficiency of a wastewater treatment plant (WWTP). Therefore, it is essential to study the effects of newly synthesized substances on the activity of activated sludge microorganisms. The aim of this study was to determine the effect of innovative biosurfactants, i.e., sophorolipids quaternary ammonium salts (SQAS), and three common micropollutants (MPs), i.e., diclofenac (DCP), 17α-ethynylestradiol (EE2), and 4-nonylenol (4-NP), on the biochemical activity of activated sludge microorganisms. The effect of all tested substances was more significant on nitrite-oxidizing bacteria (NOB) than on ammonia-oxidizing bacteria (AOB), and least on the respiratory activity of heterotrophic organisms (HET). SQAS inhibited nitrification even at the lowest concentration tested (5 mg L−1) and the inhibition degree was in the range of 37% to 78%; at the highest concentration of SQAS studied (160 mg L−1), it was about 45–96%. In most cases, the degree of inhibition increased when the SQAS concentration approached 80–160 mg L−1. MPs influenced the activity of nitrifiers to a lower extent than SQAS. The inhibition degree varied from 25% to 75%, depending on the micropollutant tested and its concentration.
Dorota Olejnik; Malgorzata Galamon; Ewa Liwarska-Bizukojc; Elisabeth Delbeke; Kevin Van Geem; Christian Stevens. Effect of Newly Synthesized Salts and Three Common Micropollutants on the Biochemical Activity of Nitrifiers. Sustainability 2021, 13, 7417 .
AMA StyleDorota Olejnik, Malgorzata Galamon, Ewa Liwarska-Bizukojc, Elisabeth Delbeke, Kevin Van Geem, Christian Stevens. Effect of Newly Synthesized Salts and Three Common Micropollutants on the Biochemical Activity of Nitrifiers. Sustainability. 2021; 13 (13):7417.
Chicago/Turabian StyleDorota Olejnik; Malgorzata Galamon; Ewa Liwarska-Bizukojc; Elisabeth Delbeke; Kevin Van Geem; Christian Stevens. 2021. "Effect of Newly Synthesized Salts and Three Common Micropollutants on the Biochemical Activity of Nitrifiers." Sustainability 13, no. 13: 7417.
Accurate thermochemistry estimation of polycyclic molecules is crucial for kinetic modeling of chemical processes that use renewable and alternative feedstocks. In kinetic model generators, molecular properties are estimated rapidly with group additivity, but this method is known to have limitations for polycyclic structures. This issue has been resolved in our work by combining a geometry-based molecular representation with a deep neural network trained on ab initio data. Each molecule is transformed into a probabilistic vector from its interatomic distances, bond angles, and dihedral angles. The model is tested on a small experimental dataset (200 molecules) from the literature, a new medium-sized set (4000 molecules) with both open-shell and closed-shell species, calculated at the CBS-QB3 level with empirical corrections, and a large G4MP2-level QM9-based dataset (40 000 molecules). Heat capacities between 298.15 and 2500 K are calculated in the medium set with an average deviation of about 1.5 J mol–1 K–1 and the standard entropy at 298.15 K is predicted with an average error below 4 J mol–1 K–1. The standard enthalpy of formation at 298.15 K has an average out-of-sample error below 4 kJ mol–1 on a QM9 training set size of around 15 000 molecules. By fitting NASA polynomials, the enthalpy of formation at higher temperatures can be calculated with the same accuracy as the standard enthalpy of formation. Uncertainty quantification by means of the ensemble standard deviation is included to indicate when molecules that are on the edge or outside of the application range of the model are evaluated.
Maarten R. Dobbelaere; Pieter P. Plehiers; Ruben Van de Vijver; Christian V. Stevens; Kevin M. Van Geem. Learning Molecular Representations for Thermochemistry Prediction of Cyclic Hydrocarbons and Oxygenates. The Journal of Physical Chemistry A 2021, 125, 5166 -5179.
AMA StyleMaarten R. Dobbelaere, Pieter P. Plehiers, Ruben Van de Vijver, Christian V. Stevens, Kevin M. Van Geem. Learning Molecular Representations for Thermochemistry Prediction of Cyclic Hydrocarbons and Oxygenates. The Journal of Physical Chemistry A. 2021; 125 (23):5166-5179.
Chicago/Turabian StyleMaarten R. Dobbelaere; Pieter P. Plehiers; Ruben Van de Vijver; Christian V. Stevens; Kevin M. Van Geem. 2021. "Learning Molecular Representations for Thermochemistry Prediction of Cyclic Hydrocarbons and Oxygenates." The Journal of Physical Chemistry A 125, no. 23: 5166-5179.
The first heterogeneously catalyzed process for the reductive coupling of imines and iminium ions is reported using precious metal catalysts in combination with hydrogen gas as the terminal reductant. The optimized method in terms of catalyst composition and reaction conditions allowed to produce aromatic vicinal diamines without the use of stoichiometric amounts of zero or low valent metals, which is currently the preferred method. The most important mechanistic features of the reaction were unraveled by a combined experimental and computational approach. The developed methodology is very efficient for the coupling of aromatic iminium ions with yields up to 88 % while imines give only low to moderate yields.
K.N.R. Dumoleijn; E. Van Den Broeck; J. Stavinoha; V. Van Speybroeck; K. Moonen; C.V. Stevens. Reductive imino-pinacol coupling reaction of halogenated aromatic imines and iminium ions catalyzed by precious metal catalysts using hydrogen. Journal of Catalysis 2021, 400, 103 -113.
AMA StyleK.N.R. Dumoleijn, E. Van Den Broeck, J. Stavinoha, V. Van Speybroeck, K. Moonen, C.V. Stevens. Reductive imino-pinacol coupling reaction of halogenated aromatic imines and iminium ions catalyzed by precious metal catalysts using hydrogen. Journal of Catalysis. 2021; 400 ():103-113.
Chicago/Turabian StyleK.N.R. Dumoleijn; E. Van Den Broeck; J. Stavinoha; V. Van Speybroeck; K. Moonen; C.V. Stevens. 2021. "Reductive imino-pinacol coupling reaction of halogenated aromatic imines and iminium ions catalyzed by precious metal catalysts using hydrogen." Journal of Catalysis 400, no. : 103-113.
An extensive overview on N‐rich antennae used in lanthanide‐based temperature sensing is provided. The investigation of different antennae is required to develop temperature sensors with diverse optical properties and to create a diverse offer for the multiple application fields. For more details see the Review by C. V. Stevens et al. on page 7214 ff.
Flore Vanden Bussche; Dr. Anna M. Kaczmarek; Dr. Veronique Van Speybroeck; Dr. Pascal Van Der Voort; Dr. Christian V. Stevens. Frontispiece: Overview of N‐Rich Antennae Investigated in Lanthanide‐Based Temperature Sensing. Chemistry – A European Journal 2021, 27, 1 .
AMA StyleFlore Vanden Bussche, Dr. Anna M. Kaczmarek, Dr. Veronique Van Speybroeck, Dr. Pascal Van Der Voort, Dr. Christian V. Stevens. Frontispiece: Overview of N‐Rich Antennae Investigated in Lanthanide‐Based Temperature Sensing. Chemistry – A European Journal. 2021; 27 (25):1.
Chicago/Turabian StyleFlore Vanden Bussche; Dr. Anna M. Kaczmarek; Dr. Veronique Van Speybroeck; Dr. Pascal Van Der Voort; Dr. Christian V. Stevens. 2021. "Frontispiece: Overview of N‐Rich Antennae Investigated in Lanthanide‐Based Temperature Sensing." Chemistry – A European Journal 27, no. 25: 1.
Nanoparticle-sensitized photoporation for safe and efficient cytosolic delivery of gadolinium chelates, enabling high-contrast in vivo cell tracking of cells by magnetic resonance imaging.
Aranit Harizaj; Benedicte Descamps; Christophe Mangodt; Stephan Stremersch; Arianna Stoppa; Lieve Balcaen; Toon Brans; Hilde De Rooster; Nausikaa Devriendt; Juan C. Fraire; Eduardo Bolea-Fernandez; Olivier De Wever; Wouter Willaert; Frank Vanhaecke; Christian V. Stevens; Stefaan C. De Smedt; Bart Roman; Christian Vanhove; Ine Lentacker; Kevin Braeckmans. Cytosolic delivery of gadolinium via photoporation enables improved in vivo magnetic resonance imaging of cancer cells. Biomaterials Science 2021, 9, 4005 -4018.
AMA StyleAranit Harizaj, Benedicte Descamps, Christophe Mangodt, Stephan Stremersch, Arianna Stoppa, Lieve Balcaen, Toon Brans, Hilde De Rooster, Nausikaa Devriendt, Juan C. Fraire, Eduardo Bolea-Fernandez, Olivier De Wever, Wouter Willaert, Frank Vanhaecke, Christian V. Stevens, Stefaan C. De Smedt, Bart Roman, Christian Vanhove, Ine Lentacker, Kevin Braeckmans. Cytosolic delivery of gadolinium via photoporation enables improved in vivo magnetic resonance imaging of cancer cells. Biomaterials Science. 2021; 9 (11):4005-4018.
Chicago/Turabian StyleAranit Harizaj; Benedicte Descamps; Christophe Mangodt; Stephan Stremersch; Arianna Stoppa; Lieve Balcaen; Toon Brans; Hilde De Rooster; Nausikaa Devriendt; Juan C. Fraire; Eduardo Bolea-Fernandez; Olivier De Wever; Wouter Willaert; Frank Vanhaecke; Christian V. Stevens; Stefaan C. De Smedt; Bart Roman; Christian Vanhove; Ine Lentacker; Kevin Braeckmans. 2021. "Cytosolic delivery of gadolinium via photoporation enables improved in vivo magnetic resonance imaging of cancer cells." Biomaterials Science 9, no. 11: 4005-4018.
The market share of noncontact temperature sensors is expending due to fast technological and medical evolutions. In the wide variety of noncontact sensors, lanthanide‐based temperature sensors stand out. They benefit from high photostability, relatively long decay times and high quantum yields. To circumvent their low molar light absorption, the incorporation of a light‐harvesting antenna is required. This review provides an overview of the nitrogen‐rich antennae in lanthanide‐based temperature sensors, emitting in the visible light spectrum, and discuss their temperature sensor ability. The N‐rich ligands are incorporated in many different platforms. The investigation of different antennae is required to develop temperature sensors with diverse optical properties and to create a diverse offer for the multiple application fields. First the molecular probes, consisting of small molecules, are discussed. Furthermore, the thermometer properties of ratiometric temperature sensors, based on di‐ and polynuclear complexes, metal‐organic‐frameworks, periodic mesoporous organosilicas and porous organic polymers, are summarized. The antenna mainly determines the application potential of the ratiometric thermometer. It can be observed that molecular probes are operational in the broad physiological range, metal‐organic‐frameworks are generally very useful in the cryogenic region, periodic mesoporous organosilica show temperature dependency in the physiological range and porous organic polymers are operative in the cryogenic to medium temperature range.
Flore Vanden Bussche; Anna M. Kaczmarek; Veronique Van Speybroeck; Pascal Van Der Voort; Christian V. Stevens. Overview of N‐Rich Antennae Investigated in Lanthanide‐Based Temperature Sensing. Chemistry – A European Journal 2021, 27, 7214 -7230.
AMA StyleFlore Vanden Bussche, Anna M. Kaczmarek, Veronique Van Speybroeck, Pascal Van Der Voort, Christian V. Stevens. Overview of N‐Rich Antennae Investigated in Lanthanide‐Based Temperature Sensing. Chemistry – A European Journal. 2021; 27 (25):7214-7230.
Chicago/Turabian StyleFlore Vanden Bussche; Anna M. Kaczmarek; Veronique Van Speybroeck; Pascal Van Der Voort; Christian V. Stevens. 2021. "Overview of N‐Rich Antennae Investigated in Lanthanide‐Based Temperature Sensing." Chemistry – A European Journal 27, no. 25: 7214-7230.
Structurally characterizing new materials is tremendously challenging, especially when single crystal structures are hardly available which is often the case for covalent organic frameworks. Yet, knowledge of the atomic structure is key to establish structure‐function relations and enable functional material design. Herein a new protocol is proposed to unambiguously predict the structure of poorly crystalline materials through a likelihood ordering based on the X‐ray diffraction (XRD) pattern. Key of the procedure is the broad set of structures generated from a limited number of building blocks and topologies, which is submitted to operando structural characterization. The dynamic averaging in the latter accounts for the operando conditions and inherent temporal character of experimental measurements, yielding unparalleled agreement with experimental powder XRD patterns. The proposed concept can hence unquestionably identify the structure of experimentally synthesized materials, a crucial step to design next generation functional materials.
Sander Borgmans; Sven M. J. Rogge; Juul S. De Vos; Christian V. Stevens; Pascal Van Der Voort; Veronique Van Speybroeck. Quantifying the Likelihood of Structural Models through a Dynamically Enhanced Powder X‐Ray Diffraction Protocol. Angewandte Chemie 2021, 1 .
AMA StyleSander Borgmans, Sven M. J. Rogge, Juul S. De Vos, Christian V. Stevens, Pascal Van Der Voort, Veronique Van Speybroeck. Quantifying the Likelihood of Structural Models through a Dynamically Enhanced Powder X‐Ray Diffraction Protocol. Angewandte Chemie. 2021; ():1.
Chicago/Turabian StyleSander Borgmans; Sven M. J. Rogge; Juul S. De Vos; Christian V. Stevens; Pascal Van Der Voort; Veronique Van Speybroeck. 2021. "Quantifying the Likelihood of Structural Models through a Dynamically Enhanced Powder X‐Ray Diffraction Protocol." Angewandte Chemie , no. : 1.
Structurally characterizing new materials is tremendously challenging, especially when single crystal structures are hardly available which is often the case for covalent organic frameworks. Yet, knowledge of the atomic structure is key to establish structure‐function relations and enable functional material design. Herein a new protocol is proposed to unambiguously predict the structure of poorly crystalline materials through a likelihood ordering based on the X‐ray diffraction (XRD) pattern. Key of the procedure is the broad set of structures generated from a limited number of building blocks and topologies, which is submitted to operando structural characterization. The dynamic averaging in the latter accounts for the operando conditions and inherent temporal character of experimental measurements, yielding unparalleled agreement with experimental powder XRD patterns. The proposed concept can hence unquestionably identify the structure of experimentally synthesized materials, a crucial step to design next generation functional materials.
Sander Borgmans; Sven M. J. Rogge; Juul S. De Vos; Christian V. Stevens; Pascal Van Der Voort; Veronique Van Speybroeck. Quantifying the Likelihood of Structural Models through a Dynamically Enhanced Powder X‐Ray Diffraction Protocol. Angewandte Chemie International Edition 2021, 60, 8913 -8922.
AMA StyleSander Borgmans, Sven M. J. Rogge, Juul S. De Vos, Christian V. Stevens, Pascal Van Der Voort, Veronique Van Speybroeck. Quantifying the Likelihood of Structural Models through a Dynamically Enhanced Powder X‐Ray Diffraction Protocol. Angewandte Chemie International Edition. 2021; 60 (16):8913-8922.
Chicago/Turabian StyleSander Borgmans; Sven M. J. Rogge; Juul S. De Vos; Christian V. Stevens; Pascal Van Der Voort; Veronique Van Speybroeck. 2021. "Quantifying the Likelihood of Structural Models through a Dynamically Enhanced Powder X‐Ray Diffraction Protocol." Angewandte Chemie International Edition 60, no. 16: 8913-8922.
The chemical literature from the last 10 years, devoted to compounds in which their spiro nature results from a phosphorus atom at the ring junction, is reviewed in this article. Data related to structures in which a spirocyclic phosphorus atom can have a coordination number of four, five, or six are discussed including bicyclic phosphonium salts 1, bicyclic ylides 2, anionic spirophosphoranides 3, spirophosphoranes with a five-coordinated spiro phosphorus atom 4, bicyclic anionic six-coordinated spirophosphorus compounds 5, tricyclic anionic six-coordinated spirophosphorus compounds 6, phosphorus analogues of fenestranes 7, anionic hexacyclic six-coordinated compounds 8, anionic tetracyclic six-coordinate derivatives 9, compounds in which a spirophosporus atom constitutes a bridgehead atom 10, compounds which have donor functional groups that can undergo dative bonding with the phosphorus center generating a spiro system 11.
Jozef Drabowicz; Rafal Karpowicz; Dorota Krasowska; Luca Sancineto; Christian V. Stevens. Compounds Containing a Spiro Phosphorus Atom. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering 2020, 1 .
AMA StyleJozef Drabowicz, Rafal Karpowicz, Dorota Krasowska, Luca Sancineto, Christian V. Stevens. Compounds Containing a Spiro Phosphorus Atom. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering. 2020; ():1.
Chicago/Turabian StyleJozef Drabowicz; Rafal Karpowicz; Dorota Krasowska; Luca Sancineto; Christian V. Stevens. 2020. "Compounds Containing a Spiro Phosphorus Atom." Reference Module in Chemistry, Molecular Sciences and Chemical Engineering , no. : 1.
The front cover artwork is provided by the groups of Prof. Veronique Van Speybroeck, Prof. Pascal Van Der Voort and Prof. Christian V. Stevens (Ghent University, Belgium). The image shows the interaction between visible light and the building blocks of covalent triazine frameworks, which are promising heterogeneous catalysts. Read the full text of the Article at 10.1002/cphc.202000592.
Liesbeth De Bruecker; Jonas Everaert; Pascal Van Der Voort; Christian V. Stevens; Michel Waroquier; Veronique Van Speybroeck. Structural and Photophysical Properties of Various Polypyridyl Ligands: A Combined Experimental and Computational Study. ChemPhysChem 2020, 21, 2488 -2488.
AMA StyleLiesbeth De Bruecker, Jonas Everaert, Pascal Van Der Voort, Christian V. Stevens, Michel Waroquier, Veronique Van Speybroeck. Structural and Photophysical Properties of Various Polypyridyl Ligands: A Combined Experimental and Computational Study. ChemPhysChem. 2020; 21 (22):2488-2488.
Chicago/Turabian StyleLiesbeth De Bruecker; Jonas Everaert; Pascal Van Der Voort; Christian V. Stevens; Michel Waroquier; Veronique Van Speybroeck. 2020. "Structural and Photophysical Properties of Various Polypyridyl Ligands: A Combined Experimental and Computational Study." ChemPhysChem 21, no. 22: 2488-2488.
Photocatalytic reduction of molecular oxygen is a promising route toward sustainable production of hydrogen peroxide (H2O2). This challenging process requires photoactive semiconductors enabling solar energy driven generation and separation of electrons and holes with high charge transfer kinetics. Covalent organic frameworks (COFs) are an emerging class of photoactive semiconductors, tunable at a molecular level for high charge carrier generation and transfer. Herein, we report two newly designed two-dimensional COFs based on a (diarylamino)benzene linker that form a Kagome (kgm) lattice and show strong visible light absorption. Their high crystallinity and large surface areas (up to 1165 m2·g–1) allow efficient charge transfer and diffusion. The diarylamine (donor) unit promotes strong reduction properties, enabling these COFs to efficiently reduce oxygen to form H2O2. Overall, the use of a metal-free, recyclable photocatalytic system allows efficient photocatalytic solar transformations.
Chidharth Krishnaraj; Himanshu Sekhar Jena; Laurens Bourda; Andreas Laemont; Pradip Pachfule; Jérôme Roeser; C. Vinod Chandran; Sander Borgmans; Sven M. J. Rogge; Karen Leus; Christian V. Stevens; Johan A. Martens; Veronique Van Speybroeck; Eric Breynaert; Arne Thomas; Pascal Van Der Voort. Strongly Reducing (Diarylamino)benzene-Based Covalent Organic Framework for Metal-Free Visible Light Photocatalytic H2O2 Generation. Journal of the American Chemical Society 2020, 142, 20107 -20116.
AMA StyleChidharth Krishnaraj, Himanshu Sekhar Jena, Laurens Bourda, Andreas Laemont, Pradip Pachfule, Jérôme Roeser, C. Vinod Chandran, Sander Borgmans, Sven M. J. Rogge, Karen Leus, Christian V. Stevens, Johan A. Martens, Veronique Van Speybroeck, Eric Breynaert, Arne Thomas, Pascal Van Der Voort. Strongly Reducing (Diarylamino)benzene-Based Covalent Organic Framework for Metal-Free Visible Light Photocatalytic H2O2 Generation. Journal of the American Chemical Society. 2020; 142 (47):20107-20116.
Chicago/Turabian StyleChidharth Krishnaraj; Himanshu Sekhar Jena; Laurens Bourda; Andreas Laemont; Pradip Pachfule; Jérôme Roeser; C. Vinod Chandran; Sander Borgmans; Sven M. J. Rogge; Karen Leus; Christian V. Stevens; Johan A. Martens; Veronique Van Speybroeck; Eric Breynaert; Arne Thomas; Pascal Van Der Voort. 2020. "Strongly Reducing (Diarylamino)benzene-Based Covalent Organic Framework for Metal-Free Visible Light Photocatalytic H2O2 Generation." Journal of the American Chemical Society 142, no. 47: 20107-20116.
Sophorolipids are one of the most important microbial biosurfactants, because of their large-scale production and applications developed so far in the fields of detergency, microbiology, cosmetics or environmental science.
Abdoul Aziz Ba; Jonas Everaert; Alexandre Poirier; Patrick Le Griel; Wim Soetaert; Sophie L. K. W. Roelants; Daniel Hermida-Merino; Christian V. Stevens; Niki Baccile. Synthesis and self-assembly of aminyl and alkynyl substituted sophorolipids. Green Chemistry 2020, 22, 8323 -8336.
AMA StyleAbdoul Aziz Ba, Jonas Everaert, Alexandre Poirier, Patrick Le Griel, Wim Soetaert, Sophie L. K. W. Roelants, Daniel Hermida-Merino, Christian V. Stevens, Niki Baccile. Synthesis and self-assembly of aminyl and alkynyl substituted sophorolipids. Green Chemistry. 2020; 22 (23):8323-8336.
Chicago/Turabian StyleAbdoul Aziz Ba; Jonas Everaert; Alexandre Poirier; Patrick Le Griel; Wim Soetaert; Sophie L. K. W. Roelants; Daniel Hermida-Merino; Christian V. Stevens; Niki Baccile. 2020. "Synthesis and self-assembly of aminyl and alkynyl substituted sophorolipids." Green Chemistry 22, no. 23: 8323-8336.
An efficient and catalyst-free method for the preparation of optically active and racemic mono-substituted t-butyl phosphinic chlorides tBuRP(O)Cl under flow conditions was reported.
Aleksandra Jasiak; Krzysztof Owsianik; Bartłomiej Gostyński; Grażyna Mielniczak; Christian V. Stevens; Józef Drabowicz. Experimental study on the microreactor-assisted synthesis of phosphinic chlorides with varying steric hindrance. Organic Chemistry Frontiers 2020, 7, 3664 -3674.
AMA StyleAleksandra Jasiak, Krzysztof Owsianik, Bartłomiej Gostyński, Grażyna Mielniczak, Christian V. Stevens, Józef Drabowicz. Experimental study on the microreactor-assisted synthesis of phosphinic chlorides with varying steric hindrance. Organic Chemistry Frontiers. 2020; 7 (22):3664-3674.
Chicago/Turabian StyleAleksandra Jasiak; Krzysztof Owsianik; Bartłomiej Gostyński; Grażyna Mielniczak; Christian V. Stevens; Józef Drabowicz. 2020. "Experimental study on the microreactor-assisted synthesis of phosphinic chlorides with varying steric hindrance." Organic Chemistry Frontiers 7, no. 22: 3664-3674.
Alterations of hydrogen peroxide (H2O2) levels have a profound impact on numerous signaling cascades orchestrating plant growth, development, and stress signaling, including programmed cell death. To expand the repertoire of known molecular mechanisms implicated in H2O2 signaling, we performed a forward chemical screen to identify small molecules that could alleviate the photorespiratory-induced cell death phenotype of Arabidopsisthaliana mutants lacking H2O2-scavenging capacity by peroxisomal catalase2. Here, we report the characterization of pakerine, an m-sulfamoyl benzamide from the sulfonamide family. Pakerine alleviates the cell death phenotype of cat2 mutants exposed to photorespiration-promoting conditions and delays dark-induced senescence in wild-type Arabidopsis leaves. By using a combination of transcriptomics, metabolomics, and affinity purification, we identified abnormal inflorescence meristem 1 (AIM1) as a putative protein target of pakerine. AIM1 is a 3-hydroxyacyl-CoA dehydrogenase involved in fatty acid β-oxidation that contributes to jasmonic acid (JA) and salicylic acid (SA) biosynthesis. Whereas intact JA biosynthesis was not required for pakerine bioactivity, our results point toward a role for β-oxidation-dependent SA production in the execution of H2O2-mediated cell death.
Tom Van Der Meer; Arno Verlee; Patrick Willems; Francis Impens; Kris Gevaert; Christa Testerink; Christian V. Stevens; Frank Van Breusegem; Pavel Kerchev. Chemical Genetics Approach Identifies Abnormal Inflorescence Meristem 1 as a Putative Target of a Novel Sulfonamide That Protects Catalase2-Deficient Arabidopsis against Photorespiratory Stress. Cells 2020, 9, 2026 .
AMA StyleTom Van Der Meer, Arno Verlee, Patrick Willems, Francis Impens, Kris Gevaert, Christa Testerink, Christian V. Stevens, Frank Van Breusegem, Pavel Kerchev. Chemical Genetics Approach Identifies Abnormal Inflorescence Meristem 1 as a Putative Target of a Novel Sulfonamide That Protects Catalase2-Deficient Arabidopsis against Photorespiratory Stress. Cells. 2020; 9 (9):2026.
Chicago/Turabian StyleTom Van Der Meer; Arno Verlee; Patrick Willems; Francis Impens; Kris Gevaert; Christa Testerink; Christian V. Stevens; Frank Van Breusegem; Pavel Kerchev. 2020. "Chemical Genetics Approach Identifies Abnormal Inflorescence Meristem 1 as a Putative Target of a Novel Sulfonamide That Protects Catalase2-Deficient Arabidopsis against Photorespiratory Stress." Cells 9, no. 9: 2026.
Chloroformylation reactions are versatile reactions that allow the introduction of a chlorine atom and an aldehyde group in enolizable ketones, employing the well-known Vilsmeier reagent. However, the use of this unstable reagent is usually associated with hazards, especially when it is used on an industrial scale. The present article describes the preparation and use of the Vilsmeier reagent under continuous flow conditions for the preparation of an important intermediate in the synthesis of cyanine dyes. In addition, the traditionally used DMF has been substituted with more desirable formamides, together with the removal of the halogenated solvent usually employed in the reaction. In consequence, the optimized conditions allow the continuous production of the target compound in 79-81 % isolated yield in a more environmentally friendly, fast and secure manner.
Manuel Carrera; Laurens De Coen; Michelle Coppens; Wim Dermaut; Christian Victor Stevens. A Vilsmeier Chloroformylation by Continuous Flow Chemistry. Organic Process Research & Development 2020, 24, 2260 -2265.
AMA StyleManuel Carrera, Laurens De Coen, Michelle Coppens, Wim Dermaut, Christian Victor Stevens. A Vilsmeier Chloroformylation by Continuous Flow Chemistry. Organic Process Research & Development. 2020; 24 (10):2260-2265.
Chicago/Turabian StyleManuel Carrera; Laurens De Coen; Michelle Coppens; Wim Dermaut; Christian Victor Stevens. 2020. "A Vilsmeier Chloroformylation by Continuous Flow Chemistry." Organic Process Research & Development 24, no. 10: 2260-2265.
A biobased pH-sensitive glycolipid derived from microbial fermentation spontaneously forms lamellar hydrogels at room temperature and pH < 8 without any gelling agent. The elastic properties derive from interconnected defectuous lamellar domains.
Ghazi Ben Messaoud; Patrick Le Griel; Sylvain Prévost; Daniel Hermida-Merino; Wim Soetaert; Sophie L. K. W. Roelants; Christian V. Stevens; Niki Baccile. Single-molecule lamellar hydrogels from bolaform microbial glucolipids. Soft Matter 2020, 16, 2528 -2539.
AMA StyleGhazi Ben Messaoud, Patrick Le Griel, Sylvain Prévost, Daniel Hermida-Merino, Wim Soetaert, Sophie L. K. W. Roelants, Christian V. Stevens, Niki Baccile. Single-molecule lamellar hydrogels from bolaform microbial glucolipids. Soft Matter. 2020; 16 (10):2528-2539.
Chicago/Turabian StyleGhazi Ben Messaoud; Patrick Le Griel; Sylvain Prévost; Daniel Hermida-Merino; Wim Soetaert; Sophie L. K. W. Roelants; Christian V. Stevens; Niki Baccile. 2020. "Single-molecule lamellar hydrogels from bolaform microbial glucolipids." Soft Matter 16, no. 10: 2528-2539.
Synergistic catalysis holds great promise to enhance the catalytic performance of heterogeneous catalysts suffering from sluggish reaction kinetics. Much effort has been dedicated to the development of bimetallic systems in which the two promoter elements display synergistic benefits compared to monometallic counterparts. However, the use of bimetallic catalysts inescapably raises the cost of preparation and environmental issues. This study discovers a synergistic effect when using a bipyridine covalent triazine framework (bipy-CTF) as support for an IrIII complex in the aerobic oxidation reaction. The detailed mechanistic study provides insights into the function of the bipy-CTF in this synergistic catalysis. The EPR and in-situ XANES analyses confirm the applicability of bipy-CTF to activate oxygen and alcohol, resulting in an enhancement of the performance of the IrIII complex to exceed the activity of the homogeneous counterpart. This is an unprecedented report on promoting the activity of a heterogeneous catalyst through its solid support.
Sara Abednatanzi; Parviz Gohari Derakhshandeh; Pieter Tack; Francesco Muniz-Miranda; Ying-Ya Liu; Jonas Everaert; Maria Meledina; Flore Vanden Bussche; Laszlo Vincze; Christian V. Stevens; Veronique Van Speybroeck; Henk Vrielinck; Freddy Callens; Karen Leus; Pascal Van Der Voort. Elucidating the promotional effect of a covalent triazine framework in aerobic oxidation. Applied Catalysis B: Environmental 2020, 269, 118769 .
AMA StyleSara Abednatanzi, Parviz Gohari Derakhshandeh, Pieter Tack, Francesco Muniz-Miranda, Ying-Ya Liu, Jonas Everaert, Maria Meledina, Flore Vanden Bussche, Laszlo Vincze, Christian V. Stevens, Veronique Van Speybroeck, Henk Vrielinck, Freddy Callens, Karen Leus, Pascal Van Der Voort. Elucidating the promotional effect of a covalent triazine framework in aerobic oxidation. Applied Catalysis B: Environmental. 2020; 269 ():118769.
Chicago/Turabian StyleSara Abednatanzi; Parviz Gohari Derakhshandeh; Pieter Tack; Francesco Muniz-Miranda; Ying-Ya Liu; Jonas Everaert; Maria Meledina; Flore Vanden Bussche; Laszlo Vincze; Christian V. Stevens; Veronique Van Speybroeck; Henk Vrielinck; Freddy Callens; Karen Leus; Pascal Van Der Voort. 2020. "Elucidating the promotional effect of a covalent triazine framework in aerobic oxidation." Applied Catalysis B: Environmental 269, no. : 118769.
Chemical processes can benefit tremendously from fast and accurate effluent composition prediction for plant design, control, and optimization. The Industry 4.0 revolution claims that by introducing machine learning into these fields, substantial economic and environmental gains can be achieved. The bottleneck for high-frequency optimization and process control is often the time necessary to perform the required detailed analyses of, for example, feed and product. To resolve these issues, a framework of four deep learning artificial neural networks (DL ANNs) has been developed for the largest chemicals production process—steam cracking. The proposed methodology allows both a detailed characterization of a naphtha feedstock and a detailed composition of the steam cracker effluent to be determined, based on a limited number of commercial naphtha indices and rapidly accessible process characteristics. The detailed characterization of a naphtha is predicted from three points on the boiling curve and PIONA (paraffin, isoparaffin, olefin, naphthene, and aromatics) characterization. If unavailable, the boiling points are also estimated. Even with estimated boiling points, the developed DL ANN outperforms several established methods such as maximization of Shannon entropy and traditional ANNs. For feedstock reconstruction, a mean absolute error (MAE) of 0.3 wt% is achieved on the test set, while the MAE of the effluent prediction is 0.1 wt%. When combining all networks—using the output of the previous as input to the next—the effluent MAE increases to 0.19 wt%. In addition to the high accuracy of the networks, a major benefit is the negligible computational cost required to obtain the predictions. On a standard Intel i7 processor, predictions are made in the order of milliseconds. Commercial software such as COILSIM1D performs slightly better in terms of accuracy, but the required central processing unit time per reaction is in the order of seconds. This tremendous speed-up and minimal accuracy loss make the presented framework highly suitable for the continuous monitoring of difficult-to-access process parameters and for the envisioned, high-frequency real-time optimization (RTO) strategy or process control. Nevertheless, the lack of a fundamental basis implies that fundamental understanding is almost completely lost, which is not always well-accepted by the engineering community. In addition, the performance of the developed networks drops significantly for naphthas that are highly dissimilar to those in the training set.
Pieter P. Plehiers; Steffen H. Symoens; Ismaël Amghizar; Guy B. Marin; Christian V. Stevens; Kevin M. Van Geem. Artificial Intelligence in Steam Cracking Modeling: A Deep Learning Algorithm for Detailed Effluent Prediction. Engineering 2019, 5, 1027 -1040.
AMA StylePieter P. Plehiers, Steffen H. Symoens, Ismaël Amghizar, Guy B. Marin, Christian V. Stevens, Kevin M. Van Geem. Artificial Intelligence in Steam Cracking Modeling: A Deep Learning Algorithm for Detailed Effluent Prediction. Engineering. 2019; 5 (6):1027-1040.
Chicago/Turabian StylePieter P. Plehiers; Steffen H. Symoens; Ismaël Amghizar; Guy B. Marin; Christian V. Stevens; Kevin M. Van Geem. 2019. "Artificial Intelligence in Steam Cracking Modeling: A Deep Learning Algorithm for Detailed Effluent Prediction." Engineering 5, no. 6: 1027-1040.