Andrea Pirkovic

Dr. Andrea Pirkovic

orcid

Research Focus & Metrics

Academic Career Length

14Years (2013-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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Verified
Journal Article
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PDF file
AVAleksandra Vilotić
Aleksandra Vilotić
MNMirjana Nacka-Aleksić
Mirjana Nacka-Aleksić
APAndrea Pirkovic
Andrea Pirkovic
ZBZanka Bojic-Trbojevic
Zanka Bojic-Trbojevic
DDDragana Dekanski
Dragana Dekanski
MKMilica Jovanović Krivokuća
Milica Jovanović Krivokuća
Interleukin-6 (IL-6) is an acknowledged inflammatory cytokine with a pleiotropic action, mediating innate and adaptive immunity and multiple physiological processes, including protective and regenerative ones. IL-8 is a pro-inflammatory CXC chemokine with a primary function in attracting and activating neutrophils, but also implicated in a variety of other cellular processes. These two ILs are abundantly expressed at the feto-maternal interface over the course of a pregnancy and have been shown to participate in numerous pregnancy-related events. In this review, we summarize the literature data regarding their role in healthy and pathological pregnancies. The general information related to IL-6 and IL-8 functions is followed by an overview of their overall expression in cycling endometrium and at the feto-maternal interface. Further, we provide an overview of their involvement in pregnancy establishment and parturition. Finally, the implication of IL-6 and IL-8 in pregnancy-associated pathological conditions, such as pregnancy loss, preeclampsia, gestational diabetes mellitus and infection/inflammation is discussed.

1 April 2014 in Toxicology in Vitro
Verified
Journal Article
Closed access
APAndrea Pirkovic
Andrea Pirkovic
LŽLada Živković
Lada Živković
DTDijana Topalovic
Dijana Topalovic
NDNinoslav Djelić
Ninoslav Djelić
VBVladan Bajić
Vladan Bajić
BSBiljana Spremo-Potparevic
Biljana Spremo-Potparevic

1 July 2017 in Colloids and Surfaces B: Biointerfaces
Verified
Journal Article
Closed access
VBVladan Bajić
Vladan Bajić
BSBiljana Spremo-Potparevic
Biljana Spremo-Potparevic
LŽLada Živković
Lada Živković
APAndrea Pirkovic
Andrea Pirkovic
JKJelena Kotur-Stevuljević
Jelena Kotur-Stevuljević
Jovan M. NedeljkovićJovan M. Nedeljković
Jovan M. Nedeljković

9 December 2022 in Nutrients
Verified
Journal Article
Open access
PDF file
MNMirjana Nacka-Aleksić
Mirjana Nacka-Aleksić
APAndrea Pirkovic
Andrea Pirkovic
AVAleksandra Vilotić
Aleksandra Vilotić
ZBZanka Bojic-Trbojevic
Zanka Bojic-Trbojevic
MKMilica Jovanović Krivokuća
Milica Jovanović Krivokuća
DDDragana Dekanski
Dragana Dekanski
Polyphenols are a group of phytochemicals with extensive biological functions and health-promoting potential. These compounds are present in most foods of plant origin and their increased widespread availability through the intake of nutritional supplements, fortified foods, and beverages, has also led to increased exposure throughout gestation. In this narrative review, we focus on the role of polyphenols in both healthy and pathological pregnancy. General information related to their classification and function is followed by an overview of their known effects in early-pregnancy events, including the current insights into molecular mechanisms involved. Further, we provide an overview of their involvement in some of the most common pregnancy-associated pathological conditions, such as preeclampsia and gestational diabetes mellitus. Additionally, we also discuss the estimated possible risk of polyphenol consumption on pregnancy outcomes. The consumption of dietary polyphenols during pregnancy needs particular attention considering the possible effects of polyphenols on the mechanisms involved in maternal adaptation and fetal development. Further studies are strongly needed to unravel the in vivo effects of polyphenol metabolites during pregnancy, as well as their role on advanced maternal age, prenatal nutrition, and metabolic risk of the offspring.

Verified
Journal Article
Open access
PDF file
MKMilica Jovanović Krivokuća
Milica Jovanović Krivokuća
AVAleksandra Vilotić
Aleksandra Vilotić
MNMirjana Nacka-Aleksić
Mirjana Nacka-Aleksić
APAndrea Pirkovic
Andrea Pirkovic
DĆDanica Ćujić
Danica Ćujić
ZBZanka Bojic-Trbojevic
Zanka Bojic-Trbojevic
Galectins are a family of conserved soluble proteins defined by an affinity for β-galactoside structures present on various glycoconjugates. Over the past few decades, galectins have been recognized as important factors for successful implantation and maintenance of pregnancy. An increasing number of studies have demonstrated their involvement in trophoblast cell function and placental development. In addition, several lines of evidence suggest their important roles in feto-maternal immune tolerance regulation and angiogenesis. Changed or dysregulated galectin expression is also described in pregnancy-related disorders. Although the data regarding galectins’ clinical relevance are still at an early stage, evidence suggests that some galectin family members are promising candidates for better understanding pregnancy-related pathologies, as well as predicting biomarkers. In this review, we aim to summarize current knowledge of galectins in early pregnancy as well as in pregnancy-related pathologies.

23 December 2014 in Journal of Alzheimer’s Disease
Verified
Journal Article
Closed access
VBVladan Bajic
Vladan Bajic
VMVesna Vranić Mandušić
Vesna Vranić Mandušić
ESElka Stefanova
Elka Stefanova
ABAna Božović
Ana Božović
RDRadoslav Davidovic
Radoslav Davidovic
BSBiljana Spremo-Potparevic
Biljana Spremo-Potparevic
X-chromosome instability has been a long established feature in Alzheimer's disease (AD). Premature centromere division and aneuploidy of the X-chromosome has been found in peripheral blood lymphocytes and neuronal tissue in female AD patients. Interestingly, only one chromosome of the X pair has been affected. These results raised a question, “Is the X-chromosome inactivation pattern altered in peripheral blood lymphocytes of women affected by AD?” To address this question, we analyzed the methylation status of androgen receptor promoter which may show us any deviation from the 50 : 50% X inactivation status in peripheral blood lymphocytes of women with AD. Our results showed skewed inactivation patterns (>90%). These findings suggest that an epigenetic alteration on the inactivation centers of the X-chromosome (or skewing) relates not only to aging, by might be a novel property that could account for the higher incidence of AD in women.