This paper considers spatiotemporal distribution and seasonal variability of aerosol optical depth (AOD) of the atmosphere at the 0.55 μm wavelength in the atmosphere over the Baikal region of Russia based on long-term data (2005–2019) from satellite observations (MODIS/AQUA). A comparison of satellite AOD values with the AERONET record at the Geophysical Observatory of Institute of Solar-Terrestrial Physics of Siberian Brunch of Russian Academy of Science was performed. The results show that interannual AOD variability is mainly due to forest fires. The highest atmospheric transparency was in 2010, 2013 and 2016, and the lowest was in 2008, 2012 and 2014. It is noted that AOD decreased with latitude with a gradient ΔAOD = 0.002 ÷ 0.001 per degree of latitude. The mean seasonal variations in AOD at the six satellite overpass points were characterized by spring (April) and summer (July) highs and low AOD values in autumn. From June to November, the drop in AOD monthly means was more than 60%.