Background: Anterior cervical discectomy and fusion (ACDF) is a common treatment for degenerative cervical spine disease, yet its frequent postoperative follow-up places substantial demands on both patients and health care systems. A digital program integrating computer-vision–guided exercise, wearable posture monitoring, and cognitive behavioral therapy (CBT) could provide remote monitoring and rehabilitation to alleviate this burden. Objective: This study aims to evaluate the clinical effectiveness and compliance of a 12-week digital rehabilitation program after ACDF compared with conventional in-person therapy. Methods: In this prospective cohort study, 336 postoperative patients self-selected either a 12-week mobile-based program incorporating computer-vision–guided exercises, wearable posture sensors, and cognitive behavioral therapy (n=270), or in-person rehabilitation group (IRG, n=66) involving weekly therapist-supervised sessions and paper-based home exercises. Digital users were stratified into a digital rehabilitation completion group (DCG, n=192) and a digital rehabilitation noncompletion group (DNG, n=78). All participants were recruited at a single tertiary hospital and returned to the clinic for outcome assessments at 0, 12, and 24 weeks postoperatively. Outcomes—primarily pain (visual analog scale [VAS]) and disability (neck disability index [NDI]), as well as 36-item short form survey mental component summary (SF-36 MCS), 3-plane cervical range of motion (ROM), muscle endurance, and patient satisfaction—were recorded at 0, 12, and 24 weeks postoperatively. All statistical analyses were performed using SPSS (version 29.0; IBM Corporation). Results were reported as means, SDs, and 95% CIs. Results: Both the DCG (n=192, who completed all digital sessions) and IRG (who completed 12 weeks of weekly in-person sessions and home exercises) demonstrated significant improvements in pain and disability at weeks 12 and 24, with no significant differences between groups ( P >.05). At Week 12, VAS decreased by −2.5 (95% CI −3.0 to −2.0) in the DCG and −2.8 (−3.7 to −1.9) in the IRG; NDI decreased by −6.8 (−10.3 to −3.3) and −8.1 (−14.3 to −1.9), respectively. At Week 24, VAS and NDI reductions reached −4.0 (−4.5 to −3.5) and −13.3 (−17.4 to −9.2) in the DCG, and −4.1 (−5.0 to −3.2) and −14.2 (−21.3 to −7.1) in the IRG. In contrast, the DNG showed minimal improvements: VAS changes were −0.8 (−1.6 to 0.0) at week 12 and −1.3 (−2.1 to −0.5) at week 24; NDI changes were −2.2 (−8.2 to 3.8) and −6.4 (−13.0 to 0.2), respectively ( P <.05 compared to DCG and IRG). Conclusions: The digital rehab program led to comparable improvements in pain, function, and mental health as conventional in-person rehab. Higher adherence was linked to better outcomes, supporting digital rehab as an effective, patient-centered approach after ACDF.