This paper introduces the preliminary results of a development project focused on waste recycling and recovery in La Paz (Bolivia). The aim is to share best practices and to present real-world challenges when implementing appropriate waste management systems in developing countries. Environmental pollution, social inequality, lack of resources, and economic discrepancies are challenges still present in the 21st century, and a global call-for-action is needed to support sustainable development. The project “LaPazRecicla”, financed by the Italian Agency for Development Cooperation, provides perspectives that are potentially useful for policy-makers, waste management practitioners, and circular economy visionaries. The article aims to present the effective contribution of the practical actions to the local municipality, and to introduce the reason for why theoretical methods were employed to support the project. The outcomes provided two main indications: on one hand, cooperation among interdisciplinary actors and financial support can give the chance of improvement, suggesting international donors should continue in this direction; on the other, political instability, lack of local technical knowledge, and the absence of planning for a long-term period makes these actions unsuitable for tangible change. Global reflections are required in order to measure the potential benefits of small-scale projects, evaluating the time needed to move towards a sustainable future in low-income countries.