Leandro M. O. Lourenço

Dr. Leandro M. O. Lourenço

Chemistry Department, University of Aveiro, Aveiro, Portugal
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Research Focus & Metrics

Academic Career Length

18Years (2009-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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10 June 2014 in Chemical Communications
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Journal Article
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Leandro M. O. LourençoLeandro M. O. Lourenço
Leandro M. O. Lourenço
Patricia PereiraPatricia Pereira
Patricia Pereira
EMElisabete Maciel
Elisabete Maciel
MVMónica Válega
Mónica Válega
FDFernando M. J. Domingues
Fernando M. J. Domingues
João ToméJoão Tomé
João Tomé
Three phthalocyanines (Pcs) conjugated with α-, β- and γ-cyclodextrins (CDs) were prepared and their application as photosensitizer (PS) agents was assessed by photophysical, photochemical and in vitro photobiological studies. The photoactivity of Pc-α-CD and Pc-γ-CD ensures their potential as PDT drugs against UM-UC-3 human bladder cancer cells.

16 November 2023 in RSC Advances
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SGSara Gamelas
Sara Gamelas
João ToméJoão Tomé
João Tomé
Augusto C. ToméAugusto C. Tomé
Augusto C. Tomé
Leandro M. O. LourençoLeandro M. O. Lourenço
Leandro M. O. Lourenço
Access to clean water is increasingly challenging worldwide due to human activities and climate change.

1 September 2021 in Journal of Photochemistry and Photobiology C: Photochemistry Reviews
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Journal Article
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CRCláudia P.S. Ribeiro
Cláudia P.S. Ribeiro
Leandro M. O. LourençoLeandro M. O. Lourenço
Leandro M. O. Lourenço

6 March 2017 in Future Medicinal Chemistry
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Journal Article
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LMLúcia Marciel
Lúcia Marciel
LTLuís Teles
Luís Teles
BMBeatriz Moreira
Beatriz Moreira
Mário PachecoMário Pacheco
Mário Pacheco
Leandro M. O. LourençoLeandro M. O. Lourenço
Leandro M. O. Lourenço
Adelaide AlmeidaAdelaide Almeida
Adelaide Almeida
Aim: Conventional disinfection techniques, considered safe for plasma, are usually associated with collateral damages on concentrated platelets and erythrocytes. Alternative methods are required an...

18 February 2019 in Molecules
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Catarina I.V: RamosCatarina I.V: Ramos
Catarina I.V: Ramos
SASusana P. Almeida
Susana P. Almeida
Leandro M. O. LourençoLeandro M. O. Lourenço
Leandro M. O. Lourenço
Patricia PereiraPatricia Pereira
Patricia Pereira
Rosa FernandesRosa Fernandes
Rosa Fernandes
Maria NevesMaria Neves
Maria Neves
The stabilization of G-Quadruplex DNA structures by ligands is a promising strategy for telomerase inhibition in cancer therapy since this enzyme is responsible for the unlimited proliferation of cancer cells. To assess the potential of a compound as a telomerase inhibitor, selectivity for quadruplex over duplex DNA is a fundamental attribute, as the drug must be able to recognize quadruplex DNA in the presence of a large amount of duplex DNA, in the cellular nucleus. By using different spectroscopic techniques, such as ultraviolet-visible, fluorescence and circular dichroism, this work evaluates the potential of a series of multicharged phthalocyanines, bearing four or eight positive charges, as G-Quadruplex stabilizing ligands. This work led us to conclude that the existence of a balance between the number and position of the positive charges in the phthalocyanine structure is a fundamental attribute for its selectivity for G-Quadruplex structures over duplex DNA structures. Two of the studied phthalocyanines, one with four peripheral positive charges (ZnPc1) and the other with less exposed eight positive charges (ZnPc4) showed high selectivity and affinity for G-Quadruplex over duplex DNA structures and were able to accumulate in the nucleus of UM-UC-3 bladder cancer cells.

16 February 2015 in Nanoscale
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LWLeonie Wibmer
Leonie Wibmer
Leandro M. O. LourençoLeandro M. O. Lourenço
Leandro M. O. Lourenço
ARAlexandra Roth
Alexandra Roth
GKGeorgios Katsukis
Georgios Katsukis
Maria NevesMaria Neves
Maria Neves
Dirk GuldiDirk Guldi
Dirk Guldi
We describe herein the preparation of novel exfoliated graphene–phthalocyanine nanohybrids, and the investigation of their photophysical properties. Pyridyl-phthalocyanines (Pcs) 1–3 are presented as novel electron accepting building blocks of variable strengths with great potential for the exfoliation of graphite via their immobilization onto the basal plane of graphene in dimethylformamide (DMF) affording single layered and turbostratic graphene based G1–G3. G1–G3 were fully characterized (AFM, TEM, Raman, steady-state and pump probe transient absorption spectroscopy) and were studied in terms of electron donor–acceptor interactions in the ground and excited states. In this context, electron transfer upon photoexcitation from graphene to the electron accepting Pcs with dynamics, for example, in G2 of <1 and 330 ± 50 ps for charge separation and charge recombination, respectively, was corroborated in a series of steady-state and time-resolved spectroscopy experiments.