Closed-loop (CL) transcutaneous auricular vagal nerve stimulation (taVNS) was officially proposed in 2020. This work firstly reviewed two existing CL-taVNS forms: motor-activated auricular vagus nerve stimulation (MAAVNS) and respiratory-gated auricular vagal afferent nerve stimulation (RAVANS), and then proposed three future CL-taVNS systems: electroencephalography (EEG)-gated CL-taVNS, electrocardiography (ECG)-gated CL-taVNS, and subcutaneous humoral signals (SHS)-gated CL-taVNS. We also highlighted the mechanisms, targets, technical issues, and patterns of CL-taVNS. By reviewing, proposing, and highlighting, this work might draw a preliminary blueprint for the development of CL-taVNS.

Diabetic mellitus (DM) poses a significant challenge and stress to global health, comparing the burden of disease in the world’s three most populous countries while projecting changes in trends in age-standardized rate (ASR) -deaths and disability adjusted life years (DALYs) up to 2050. Using GBD2021 data, we examined DM trends in China, US, India and globally for 1990–2021, and projected deaths and DALYs for DM (types 1 and 2) for 2022–2050 using Bayesian age-period-cohort (BAPC) model. It was found that the ASR-DALYs and deaths for T1DM are trending downward globally, while those for T2DM are trending upward. In terms of gender differences, the burden of T1DM by gender was insignificant, whereas the burden of disease was significantly higher in men with T2DM than in women. The burden of disease for T1DM peaks around the ages of 40–44 years, while the burden of disease for T2DM peaks at 65–69 years. Population growth and ageing are major factors influencing the disease burden of diabetes. The projection of ASR-deaths and DALYs globally for 2022–2050 showed a decreasing trend in T1DM and an increasing trend in T2DM (especially in China and India). The increasing burden of T2DM disease globally and in three countries by 2050 should be taken seriously.

Objective: Fibromyalgia (FM) is a prevalent chronic disorder characterized by widespread skeletal muscle pain. In recent years, complementary and alternative medicine (CAM) has increasingly been recognized for its potential in treating FM symptoms. This study aims to assess the efficacy of CAM therapies in mitigating the symptoms of FM. Methods: This systematic review was registered with INPLASY. A thorough search of both English and Chinese databases was undertaken from their inception until April 15, 2023. The search criteria focused on prospective controlled trials examining CAM therapies in FM patients. The statistical analysis employed mean values and standard deviations. Additionally, an evaluation of the literature’s quality and potential biases was conducted. Results: The search yielded 41 articles, encompassing 2877 FM patients and involving 20 different interventions. All studies were randomized controlled trials (RCTs). The results of the network meta-analysis (NMA) indicated that a combination of Acupuncture and Massage therapy, as well as Navel Needling therapy, effectively alleviated pain symptoms in FM patients. Furthermore, Abdominal Acupuncture and Electroacupuncture were found to be beneficial in improving patients’ mood and sleep quality. Conclusion: Acupuncture + Massage and Umbilical Acupuncture emerged as the most efficacious therapies in relieving pain symptoms in FM patients. Abdominal Acupuncture and Electroacupuncture demonstrated their effectiveness in enhancing mood and sleep quality. Overall, CAM therapies exhibited a high safety profile for patients with fibromyalgia.

This study aimed to assess the burden of respiratory tract cancers in China, the United States, India, and worldwide from 1990 to 2021. Also, forecast the evolution of respiratory tract cancers deaths and DALYs burden during 2022 to 2050. An epidemiological analysis. Based on the GBD 2021 data, this article analyzed and discussed the trends in burden of respiratory tract cancers in China, the United States, India, and the world from 1990 to 2021. Additionally, the Bayesian Age-Period-Cohort (BAPC) model was used to forecast the evolution of respiratory tract cancers deaths and DALYs burden during 2022 to 2050. The ASR-Deaths and ASR-DALYs for laryngeal and TBL cancers decreased globally. The burden of disease for TBL cancer increased in China and India (AAPC: 0.38 and 0.69), especially among Chinese women, while laryngeal cancer declined in India (AAPC: -0.69). In contrast, the burden of disease for both cancers declined substantially in the United States (-1.82 AAPC for laryngeal cancer and − 1.74 AAPC for TBL). A notable gender disparity existed in the burden of respiratory tumors, with males experienced a higher disease burden compared to females. In terms of age, the peak incidence of respiratory tract cancers predominantly occurred among individuals aged 65–74, indicating a clear tendency towards a higher prevalence among this age group. Population growth and ageing were primary factors influencing the mortality burden of larynx cancer, whereas epidemiological shifts in TBL cancer markedly impacted DALYs. The forecasted results for ASR-Deaths and ASR-DALYs worldwide from 2022 to 2050 indicated a decline in the burden of both larynx and TBL cancers. However, the deaths and DALYs of TBL cancer in China will show an upward trend, especially for females. The disease burden of respiratory tract cancers is a global health issue that needs attention, and situations vary from country to country, requiring personalized measures. Global strategies must address aging populations and socioeconomic disparities to reduce inequities in high-burden regions.

Bruton's tyrosine kinase (BTK), a key B-cell and macrophage kinase, plays a pivotal role in oncogenic pathways in many B-cell malignancies. BTK inhibitors have shown promising anti-tumor activity, first in B-cell malignancies and subsequently in other tumors. However, the prognostic role of BTK in human tumors remains largely unexplored. In this study, we aim to explore the prognostic value of BTK expression in 33 human tumors using pan-cancer analyses. Survival analyses, including Kaplan-Meier analysis and Cox analysis, were performed to explore the prognostic value of BTK for pan-cancer based on survival data from The Cancer Genome Atlas (TCGA) database. Spearman’s correlation analysis was conducted to determine the interrelations between BTK and tumor mutational burden (TMB) and between BTK and microsatellite instability (MSI). The Estimation of Stromal and Immune cells in Malignant Tumor tissues using the Expression data (ESTIMATE) algorithm was used to explore the association of BTK with the tumor microenvironment and Gene Set Enrichment Analysis (GSEA) was used to examine the underlying mechanisms of BTK’s role in multiple tumors. BTK expression is closely associated with the prognosis of head and neck squamous cell carcinoma (HNSC), brain lower grade glioma (LGG), skin cutaneous melanoma (SKCM), and lung adenocarcinoma (LUAD). BTK expression was correlated with clinical stage, TMB, and MSI in 10 types of tumors. In HNSC, LGG, LUAD, and SKCM, BTK expression was positively correlated with immune and stromal scores. BTK is a prognostic biomarker in multiple tumors, especially in HNSC, LGG, LUAD, and SKCM, and this is closely associated with tumor microenvironment remodeling.