The Erlian Basin is one of the most significant uranium-producing basins in China, mainly yielding two types of uranium deposits: roll-front (e.g., sandstone-related) and sedimentary-diagenetic (e.g., mudstone-siltstone-related). Although geophysical research has provided valuable insight into sandstone-hosted uranium deposits, there is a paucity of findings regarding mudstone-siltstone-related uranium mineralization. Therefore, the geophysical characteristics of mudstone-siltstone-related uranium deposits remain unclear, and a cost-effective prediction pattern on geophysical data has yet to be created. To address these challenges, we used integrated geophysical exploration methods (e.g., gravitational surveying, ground magnetic prospecting, radon surveying, electromagnetic surveying, and seismic exploration) to study the Nuheting syn-sedimentary-diagenetic uranium deposits (SDUD), which represent the largest mudstone-siltstone-related deposits in this basin. The results revealed the essential geophysical response characteristics associated with uranium-favorable sites. These areas tend to exhibit low-medium magnetic and gravity readings; a distinct pattern of soil radon anomalies was noted, following a “high-low-high” trend at these sites; the geophysical properties of the upper member of the target formation indicate low resistivity and unstable seismic facies, whereas the lower layers show high resistivity and scrambled seismic facies. Furthermore, this type of uranium mineralization often occurs in a “U”-shaped stratigraphic formation, typically situated in regions underlying faults. Based on the findings, we established a prediction pattern of the SDUD for the first time. In conclusion, a combination of gravitational, magnetic, radon, electromagnetic, and seismic prospecting techniques proves to be a method for effectively estimating U environments, and it is more efficient than any single approach in exploring the SDUD. Furthermore, the geophysical prediction pattern we develop allows for the economical and efficient discovery of similar SDUD in sedimentary basins. By optimizing the use of integrated geophysical techniques, this approach enhances uranium exploration while reducing the time and costs associated with traditional methods.