DNA methylation is a process in which methyl (CH3) groups are added to the DNA molecule. The DNA segment does not change in the sequence, but DNA methylation could alter the action of DNA. Different enzymes like DNA methyltransferases (DNMTs) take part in methylation of cytosine/adenine nucleosides in DNA. In prokaryotes, DNA methylation is performed to prevent the attack of phage and also plays a role in the chromosome replication and repair. In fungi, DNA methylation is studied to see the transcriptional changes, as in insects, the DNA methylation is not that well-known, it plays a different role like other organisms. In mammals, the DNA methylation is related to different types of cancers and plays the most important role in the placental development and abnormal DNA methylation connected with diseases like cancer, autoimmune diseases, and rheumatoid arthritis. Graphical abstract

Background;Propose of presence study was to evaluate the knowledge of Baluchistan’s people about cancer. Cancer is a disease which can occur at any time, any age and anywhere in the world. It is caused basically by certain types of disease, infection, mutation and due to genetic abnormalities. Method; For purpose to check the basic awareness of people of Baluchistan province (Pakistan) a randomized survey was design. Almost 1200 subjects from district Quetta, Killa Abdullah and Zhob were interviewed. Results; Results showed that people of living in urban areas had more basic awareness about cancer than other rural ones. Conclusion; It has been concluded that it is because of educational difference the awareness level is also different. As there is more educational development in urban areas as compare to rural areas so people living in rural lack basic awareness about cancer.