The search for a consistent and empirically established quantum theory of gravity is among the biggest open problems of fundamental physics. The obstacles are of formal and of conceptual nature. Here, I address the main conceptual problems, discuss their present status, and outline further directions of research. For this purpose, the main current approaches to quantum gravity are briefly reviewed and compared.

We apply the formalism of quantum cosmology to models containing a phantom field. Three models are discussed explicitly: a toy model, a model with an exponential phantom potential, and a model with phantom field accompanied by a negative cosmological constant. In all these cases we calculate the classical trajectories in configuration space and give solutions to the Wheeler-DeWitt equation in quantum cosmology. In the cases of the toy model and the model with exponential potential we are able to solve the Wheeler-DeWitt equation exactly. For comparison, we also give the corresponding solutions for an ordinary scalar field. We discuss, in particular, the behavior of wave packets in minisuperspace. For the phantom field these packets disperse in the region that corresponds to the big-rip singularity. This thus constitutes a genuine quantum region at large scales, described by a regular solution of the Wheeler-DeWitt equation. For the ordinary scalar field, the big-bang singularity is avoided. Some remarks on the arrow of time in phantom models as well as on the relation of phantom models to loop quantum cosmology are given.

We derive the primordial power spectrum of density fluctuations in the framework of quantum cosmology. For this purpose we perform a Born-Oppenheimer approximation to the Wheeler-DeWitt equation for an inflationary universe with a scalar field. In this way, we first recover the scale-invariant power spectrum that is found as an approximation in the simplest inflationary models. We then obtain quantum gravitational corrections to this spectrum and discuss whether they lead to measurable signatures in the cosmic microwave background anisotropy spectrum. The nonobservation so far of such corrections translates into an upper bound on the energy scale of inflation.

Classical models for dark energy can exhibit a variety of singularities, many of which occur for scale factors much bigger than the Planck length. We address here the issue of whether some of these singularities, the big freeze and the big démarrage, can be avoided in quantum cosmology. We use the framework of quantum geometrodynamics. We restrict our attention to a class of models whose matter content can be described by a generalized Chaplygin gas and be represented by a scalar field with an appropriate potential. Employing the DeWitt criterion that the wave function be zero at the classical singularity, we show that a class of solutions to the Wheeler-DeWitt equation fulfilling this condition can be found. These solutions thus avoid the classical singularity. We discuss the reasons for the remaining ambiguity in fixing the solution.

We continue our study on corrections from canonical quantum gravity to the power spectra of gauge-invariant inflationary scalar and tensor perturbations. A direct canonical quantization of a perturbed inflationary universe model is implemented, which leads to a Wheeler-DeWitt equation. For this equation, a semiclassical approximation is applied in order to obtain a Schrödinger equation with quantum-gravitational correction terms, from which we calculate the corrections to the power spectra. We go beyond the de Sitter case discussed earlier and analyze our model in the first slow-roll approximation, considering terms linear in the slow-roll parameters. We find that the dominant correction term from the de Sitter case, which leads to an enhancement of power on the largest scales, gets modified by terms proportional to the slow-roll parameters. A correction to the tensor-to-scalar ratio is also found at second order in the slow-roll parameters. Making use of the available experimental data, the magnitude of these quantum-gravitational corrections is estimated. Finally, the effects for the temperature anisotropies in the cosmic microwave background are qualitatively obtained.