Jeong JY, et al. J Korean Med Sci. 2018 Oct;33(50):e299. https://doi.org/10.3346/jkms.2018.33.e299

Jeong JY, et al. J Korean Med Sci. 2017 Sep;32(9):1484-1490. https://doi.org/10.3346/jkms.2017.32.9.1484

Objective: We evaluated the prognostic impacts of body composition components measured by computed tomography (CT) in patients with liver cirrhosis. Methods: A total of 160 cirrhotic patients who underwent CT and hepatic venous pressure gradient measurements were retrospectively enrolled. Cross-sectional areas of skeletal muscle, visceral and subcutaneous fat, and mean CT attenuation of trabecular bone of the fourth lumbar vertebral level (L4_HU) were measured. Results: Multivariate analysis showed model for end-stage liver disease score [hazard ratio (HR), 1.086; 95% confidence interval (CI), 1.020–1.156; P = 0.010], hepatic venous pressure gradient (HR, 1.076; 95% CI, 1.021–1.135; P = 0.006), sarcopenia (HR, 1.890; 95% CI, 1.032–3.462; P = 0.039), and L4_HU (HR, 1.960 for L4_HU <145 Hounsfield units; 95% CI, 1.094–3.512; P = 0.024) were independently associated with long-term mortality. In patients with decompensated cirrhosis, subcutaneous adipose tissue index was the only independent predictor (HR, 0.984; 95% CI, 0.969–0.999; P = 0.039). Conclusion: Body composition abnormalities determined by CT are associated with long-term prognosis in cirrhotic patients.

Choi CW, et al. Infect Chemother. 2022 Dec;54:e94. https://doi.org/10.3947/ic.2022.0122