Fully automated and volumetric segmentation of critical tumors may play a crucial role in diagnosis and surgical planning. One of the most challenging tumor segmentation tasks is localization of pancreatic ductal adenocarcinoma (PDAC). Exclusive application of conventional methods does not appear promising. Deep learning approaches has achieved great success in the computer aided diagnosis, especially in biomedical image segmentation. This paper introduces a framework based on convolutional neural network (CNN) for segmentation of PDAC mass and surrounding vessels in CT images by incorporating powerful classic features, as well. First, a 3D-CNN architecture is used to localize the pancreas region from the whole CT volume using 3D Local Binary Pattern (LBP) map of the original image. Segmentation of PDAC mass is subsequently performed using 2D attention U-Net and Texture Attention U-Net (TAU-Net). TAU-Net is introduced by fusion of dense Scale-Invariant Feature Transform (SIFT) and LBP descriptors into the attention U-Net. An ensemble model is then used to cumulate the advantages of both networks using a 3D-CNN. In addition, to reduce the effects of imbalanced data, a multi-objective loss function is proposed as a weighted combination of three classic losses including Generalized Dice Loss (GDL), Weighted Pixel-Wise Cross Entropy loss (WPCE) and boundary loss. Due to insufficient sample size for vessel segmentation, we used the above-mentioned pre-trained networks and fine-tuned them. Experimental results show that the proposed method improves the Dice score for PDAC mass segmentation in portal-venous phase by 7.52% compared to state-of-the-art methods in term of DSC. Besides, three dimensional visualization of the tumor and surrounding vessels can facilitate the evaluation of PDAC treatment response.

This paper presents the results of morphological heart arrhythmia detection based on features of electrocardiography, ECG, signal. These signals are obtained from MIT/BIH arrhythmia database. The ECG beats were first modeled using Hermitian basis functions, (HBF). In this step, the width parameter, sigma, of HBF was optimized to minimize the model error. Then, the feature vector which consists of the parameters of the model is used as an input to k-nearest neighbor, kNN, classifier to examine the efficiency of the model. In our experiments, seven different types of arrhythmias have been considered. We achieved the sensitivity of 99.00% and specificity of 99.84% which are comparable to previous works. These results were obtained in less than 0.6 second which is suitable for real-time diagnosis of heart arrhythmias

The use of intra-operative imaging system as an intervention solution to provide more accurate localization of complicated structures has become a necessity during the neurosurgery. However, due to the limitations of conventional imaging systems, high-quality real-time intra-operative imaging remains as a challenging problem. Meanwhile, photoacoustic imaging has appeared so promising to provide images of crucial structures such as blood vessels and microvasculature of tumors. To achieve high-quality photoacoustic images of vessels regarding the artifacts caused by the incomplete data, we proposed an approach based on the combination of time-reversal (TR) and deep learning methods. The proposed method applies a TR method in the first layer of the network which is followed by the convolutional neural network with weights adjusted to a set of simulated training data for the other layers to estimate artifact-free photoacoustic images. It was evaluated using a generated synthetic database of vessels. The mean of signal to noise ratio (SNR), peak SNR, structural similarity index, and edge preservation index for the test data were reached 14.6 dB, 35.3 dB, 0.97 and 0.90, respectively. As our results proved, by using the lower number of detectors and consequently the lower data acquisition time, our approach outperforms the TR algorithm in all criteria in a computational time compatible with clinical use.

In this paper, we present a novel blind watermarking method with secret key by embedding ECG signals in medical images. The embedding is done when the original image is compressed using the embedded zero-tree wavelet (EZW) algorithm. The extraction process is performed at the decompression time of the watermarked image. Our algorithm has been tested on several CT and MRI images and the peak signal to noise ratio (PSNR) between the original and watermarked image is greater than 35 dB for watermarking of 512 to 8192 bytes of the mark signal. The proposed method is able to utilize about 15% of the host image to embed the mark signal. This marking percentage has improved previous works while preserving the image details