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Dr Hooshang Lahooti is Principal Scientist and conjoint lecturer, Nepean Clinical School, University of Sydney, and a PhD in Molecular and Cellular Biology, teaching Evidence-Based Medicine. Dr Lahooti's primary research focus is on Molecular Genetics of Thyroid Eye Disease (Thyroid Ophthalmopathy), has published many articles on Autoimmune Thyroid Disorders, and has developed a unique laboratory test which has been found to be useful by ophthalmologists and endocrinologists for managing patients with various eye and thyroid disorders. Dr Lahooti worked in the following research institutes: •University of Bergen, Norway •Imperial Cancer Research Fund, in London, UK, and The University of Kentucky in Lexington, USA •Sir Charles Gairdner Hospital, Western Australia and The Discipline of Pathology, University of Tasmania •Department of Pathology, Royal Victoria Infirmary and the University of Newcastle Upon Tyne, UK •Department of Haematology and blood diseases, St. Vincent Hospital, Sydney (Garvan Institute of Medical Research) and The Children’s Hospital at Westmead
When it comes to COVID-19, access to reliable data is vital. It is crucial for the scientific community to use data reported by independent territories worldwide. This study evaluates the reliability of the pandemic data disclosed by 182 countries worldwide. We collected and assessed conformity of COVID-19 daily infections, deaths, tests, and vaccinations with Benford’s law since the beginning of the coronavirus pandemic. It is commonly accepted that the frequency of leading digits of the pandemic data shall conform to Benford’s law. Our analysis of Benfordness elicits that most countries partially distributed reliable data over the past eighteen months. Notably, the UK, Australia, Spain, Israel, and Germany, followed by 22 different nations, provided the most reliable COVID-19 data within the same period. In contrast, twenty-six nations, including Tajikistan, Belarus, Bangladesh, and Myanmar, published less reliable data on the coronavirus spread. In this context, over 31% of countries worldwide seem to have improved reliability. Our measurement of Benfordness moderately correlates with Johns Hopkin’s Global Health Security Index, suggesting that the quality of data may depend on national healthcare policies and systems. We conclude that economically or politically distressed societies have declined in conformity to the law over time. Our results are particularly relevant for policymakers worldwide.
Noah Farhadi; Hooshang Lahooti. Are COVID-19 Data Reliable? A Quantitative Analysis of Pandemic Data from 182 Countries. COVID 2021, 1, 137 -152.
AMA StyleNoah Farhadi, Hooshang Lahooti. Are COVID-19 Data Reliable? A Quantitative Analysis of Pandemic Data from 182 Countries. COVID. 2021; 1 (1):137-152.
Chicago/Turabian StyleNoah Farhadi; Hooshang Lahooti. 2021. "Are COVID-19 Data Reliable? A Quantitative Analysis of Pandemic Data from 182 Countries." COVID 1, no. 1: 137-152.
In this review we discuss the significance of the main ultrasonographic features of common thyroid and parathyroid conditions, with a focus on the advantages of real time observation. The thyroid specialist, defined as an endocrinologist with a major interest in thyroid disorders and access to a portable ultrasound machine, can correlate what they see with the thyroid blood test results and clinical findings in a way that is not available to the general endocrinologist who relies on the interpretation by the consultant radiologist of ultrasound images prepared by a technician. We also discuss the significance of the small, very bright, intra nodular microcalcifications found in benign colloid nodules, which we call “colloid spots” and the difference between these and the 3–4 mm soft microcalcifications that are 90% specific for papillary thyroid cancer and provide a new system for staging the inflammatory changes in Hashimoto thyroiditis, as observed on ultrasonography.
Jack Wall; Bernard Champion; Samer El-Kaissi; Hooshang Lahooti. Ultrasonographic Findings in Common Thyroid and Parathyroid Disorders—Advantages of Real Time Observation by the Endocrinologist with their Own Ultrasound Machine. Reports 2021, 4, 8 .
AMA StyleJack Wall, Bernard Champion, Samer El-Kaissi, Hooshang Lahooti. Ultrasonographic Findings in Common Thyroid and Parathyroid Disorders—Advantages of Real Time Observation by the Endocrinologist with their Own Ultrasound Machine. Reports. 2021; 4 (1):8.
Chicago/Turabian StyleJack Wall; Bernard Champion; Samer El-Kaissi; Hooshang Lahooti. 2021. "Ultrasonographic Findings in Common Thyroid and Parathyroid Disorders—Advantages of Real Time Observation by the Endocrinologist with their Own Ultrasound Machine." Reports 4, no. 1: 8.
Single nucleotide polymorphism 1623 A/G (rs180195) in the promoter of the Thyroglobulin gene is associated with autoimmune thyroid disease but not with thyroid ophthalmopathy Hooshang Lahooti,1,2 Senarath Edirimanne,1,2 John P Walsh,3,4 Leigh Delbridge,5,6 Emily J Hibbert,1,2 Jack R Wall1,2 1Thyroid Research Laboratory, Sydney Medical School â
Hooshang Lahooti; Senarath Edirimanne; John Walsh; Leigh Delbridge; Emily J Hibbert; Jack R Wall. Single nucleotide polymorphism 1623 A/G (rs180195) in the promoter of the Thyroglobulin gene is associated with autoimmune thyroid disease but not with thyroid ophthalmopathy. Clinical Ophthalmology 2017, ume 11, 1337 -1345.
AMA StyleHooshang Lahooti, Senarath Edirimanne, John Walsh, Leigh Delbridge, Emily J Hibbert, Jack R Wall. Single nucleotide polymorphism 1623 A/G (rs180195) in the promoter of the Thyroglobulin gene is associated with autoimmune thyroid disease but not with thyroid ophthalmopathy. Clinical Ophthalmology. 2017; ume 11 ():1337-1345.
Chicago/Turabian StyleHooshang Lahooti; Senarath Edirimanne; John Walsh; Leigh Delbridge; Emily J Hibbert; Jack R Wall. 2017. "Single nucleotide polymorphism 1623 A/G (rs180195) in the promoter of the Thyroglobulin gene is associated with autoimmune thyroid disease but not with thyroid ophthalmopathy." Clinical Ophthalmology ume 11, no. : 1337-1345.
Novel single-nucleotide polymorphisms in the calsequestrin-1 gene are associated with Graves’ ophthalmopathy and Hashimoto’s thyroiditis Hooshang Lahooti,1,2 Daniele Cultrone,1,2 Senarath Edirimanne,1,2 John P Walsh,3,4 Leigh Delbridge,5,6 Patrick Cregan,1,2 Bernard Champion,1,2 Jack R Wall1,21Thyroid Research Laboratory, Sydney Medical School – Nepean Clinical School, The University of Sydney, 2Nepean Blue Mountains Local Health District, Nepean Hospital, Kingswood, NSW, 3Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, 4School of Medicine and Pharmacology, The University of Western Australia, Crawley, WA, 5Department of Surgery, Royal North Shore Hospital, 6Sydney Medical School – Northern Clinical School, The University of Sydney, St Leonards, NSW, AustraliaBackground: The eye disorder associated with Graves’ disease, called Graves’ ophthalmopathy (GO), greatly reduces the quality of life in affected patients. Expression of the calsequestrin (CASQ1) protein in thyroid tissue may be the trigger for the development of eye muscle damage in patients with GO. We determined the prevalence of rs74123279, rs3747673, and rs2275703 single-nucleotide polymorphism (SNPs) in patients with autoimmune thyroid disorders, GO, Graves’ hyperthyroidism (GH), or Hashimoto’s thyroiditis (HT) and control subjects with no personal or family history of autoimmune thyroid disorders. Furthermore, we measured the concentration of the CASQ1 protein in normal and Graves’ thyroid tissue, correlating levels with parameters of the eye signs, CASQ1 antibody levels, and the CASQ1 gene polymorphism rs74123279 and rs2275703.Methods: High-quality genomic DNA was isolated from fresh blood samples, assayed for identification of rs74123279, rs3747673, and rs2275703 SNPs in CASQ1 gene by MassARRAY SNP analysis using iPLEX technology of SEQUENOM.Results: DNA samples from 300 patients and 106 control subjects (100 males, 306 females) with GO (n=74), GH (n=130), HT (n=96) and control subjects (n=106) were genotyped for the SNPs rs74123279, rs3747673 (n=405), and rs2275703 (n=407). The SNP rs74123279, rs3747673, and rs2275703 were identified as 1) common homozygous or wild type, 2) heterozygote, and 3) rare homozygous. Minor allele frequency for rs74123279, rs3747763, and rs2275703 were 21%, 40%, and 44%, respectively. Multiple comparisons of genotype frequency for rs74123279, rs3747763, and rs2275703 in the GO, GH, HT, and control groups showed P=0.06, 0.641, and 0.189, respectively. These results were substantiated by multiple comparison of alleles frequency for rs74123279, rs3838216, rs3747763, and rs2275703 in the GO, GH, HT, and control groups showed, P=0.36, 0.008, 0.66, and 0.05, respectively. Pairwise analysis of alleles frequency distribution in patients with GO showed significant probability for rs2275703, P=0.008.Conclusion: Based on their evolutionary conservation and their significant prevalence, we suggest that CASQ1 gene SNPs rs74123279, rs3838216, and rs2275703 may be considered as genetic markers for GO.Keywords: thyroid eye disease, autoimmune thyroiditis, ophthalmology, orbitopathy, eye muscles antibodies, wild-type, homozygous, heterozygous, genotyping
Hooshang Lahooti; Daniele Cultrone; Senarath Edirimanne; John P Walsh; Leigh Delbridge; Patrick Cregan; Jack R Wall; Bernard Champion. Novel single-nucleotide polymorphisms in the calsequestrin-1 gene are associated with Graves’ ophthalmopathy and Hashimoto’s thyroiditis. Clinical Ophthalmology 2015, ume 9, 1731 -1740.
AMA StyleHooshang Lahooti, Daniele Cultrone, Senarath Edirimanne, John P Walsh, Leigh Delbridge, Patrick Cregan, Jack R Wall, Bernard Champion. Novel single-nucleotide polymorphisms in the calsequestrin-1 gene are associated with Graves’ ophthalmopathy and Hashimoto’s thyroiditis. Clinical Ophthalmology. 2015; ume 9 ():1731-1740.
Chicago/Turabian StyleHooshang Lahooti; Daniele Cultrone; Senarath Edirimanne; John P Walsh; Leigh Delbridge; Patrick Cregan; Jack R Wall; Bernard Champion. 2015. "Novel single-nucleotide polymorphisms in the calsequestrin-1 gene are associated with Graves’ ophthalmopathy and Hashimoto’s thyroiditis." Clinical Ophthalmology ume 9, no. : 1731-1740.
Ophthalmopathy is a common manifestation of Graves’ disease (GD) occurring in up to 50% of patients. Mild eye signs are also common in patients with Hashimoto’s thyroiditis. Whilst a genetic predisposition to GD has been demonstrated this is not the case for the ophthalmopathy which often runs a separate course.
Melissa Ardley; Thomas McCorquodale; Hooshang Lahooti; Bernard Champion; Jack R Wall. Eye findings and immunological markers in probands and their euthyroid relatives from a single family with multiple cases of thyroid autoimmunity. Thyroid Research 2012, 5, 4 -4.
AMA StyleMelissa Ardley, Thomas McCorquodale, Hooshang Lahooti, Bernard Champion, Jack R Wall. Eye findings and immunological markers in probands and their euthyroid relatives from a single family with multiple cases of thyroid autoimmunity. Thyroid Research. 2012; 5 (1):4-4.
Chicago/Turabian StyleMelissa Ardley; Thomas McCorquodale; Hooshang Lahooti; Bernard Champion; Jack R Wall. 2012. "Eye findings and immunological markers in probands and their euthyroid relatives from a single family with multiple cases of thyroid autoimmunity." Thyroid Research 5, no. 1: 4-4.