Koh Mizuno

Dr. Koh Mizuno

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Research Focus & Metrics

Academic Career Length

25Years (2002-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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31 May 2012 in Journal of Physiological Anthropology
Verified
Journal Article
Open access
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KOKazue Okamoto-Mizuno
Kazue Okamoto-Mizuno
KMKoh Mizuno
Koh Mizuno
The thermal environment is one of the most important factors that can affect human sleep. The stereotypical effects of heat or cold exposure are increased wakefulness and decreased rapid eye movement sleep and slow wave sleep. These effects of the thermal environment on sleep stages are strongly linked to thermoregulation, which affects the mechanism regulating sleep. The effects on sleep stages also differ depending on the use of bedding and/or clothing. In semi-nude subjects, sleep stages are more affected by cold exposure than heat exposure. In real-life situations where bedding and clothing are used, heat exposure increases wakefulness and decreases slow wave sleep and rapid eye movement sleep. Humid heat exposure further increases thermal load during sleep and affects sleep stages and thermoregulation. On the other hand, cold exposure does not affect sleep stages, though the use of beddings and clothing during sleep is critical in supporting thermoregulation and sleep in cold exposure. However, cold exposure affects cardiac autonomic response during sleep without affecting sleep stages and subjective sensations. These results indicate that the impact of cold exposure may be greater than that of heat exposure in real-life situations; thus, further studies are warranted that consider the effect of cold exposure on sleep and other physiological parameters.

HSHideki SHIMAMOTO
Hideki SHIMAMOTO
Masataka SUWAMasataka SUWA
Masataka SUWA
KMKoh Mizuno
Koh Mizuno
In Japan and other developed countries, the lifestyles of many—particularly the younger generation—have been disrupted in recent years. This disruption may manifest as a decrease in physical activity and deterioration in the quality and quantity of sleep. Depressive tendencies are also increasing among university students. This study examined the relationship between mental health, physical activity, physical fitness, and daytime sleepiness. Eighty-five undergraduate students participated in this study (52 men and 33 women, aged 18.9 (±1.4) years). Physical activity levels were measured using an accelerometer (Lifecorder, Kenz, Nagoya, Japan) for two weeks. To evaluate their level of physical fitness, maximal oxygen uptake (V˙O2max) was calculated by an indirect method using a cycle ergometer. Depressive tendencies and daytime sleepiness were evaluated using the Patient Health Questionnaire (PHQ-9). The PHQ-9 score was positively correlated with sleepiness (r = 0.35, p = 0.001) and total steps per day (r = 0.39, p < 0.001). Moreover, the PHQ-9 score was positively correlated with V˙O2max (r = 0.25, p = 0.019). The PHQ-9 score was higher in students with good exercise habits or part-time jobs. An important finding was the positive correlation between depression and variables related to physical activity levels. These results suggest that vigorous physical activity, such as exercise and part-time jobs, might be positively associated with depressive tendencies among university students.

1 September 2016 in Journal of Physiological Anthropology
Verified
Journal Article
Open access
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KMKoh Mizuno
Koh Mizuno
AMAkiko Matsumoto
Akiko Matsumoto
TATatsuya Aiba
Tatsuya Aiba
TATakashi Abe
Takashi Abe
HOHiroshi Ohshima
Hiroshi Ohshima
YIYuichi Inoue
Yuichi Inoue
Flight controllers of the International Space Station (ISS) are engaged in shift work to provide 24-h coverage to support ISS systems. The purpose of this study was to investigate the prevalence and associated factors of shift work sleep disorder (SWSD) among Japanese ISS flight controllers. A questionnaire study was conducted using the Standard Shiftwork Index to evaluate sleep-related problems and possible associated variables. Among 52 respondents out of 73 flight controllers, 30 subjects were identified as night shift workers who worked 3 or more night shifts per month. Those night shift workers who answered “almost always” to questions about experiencing insomnia or excessive sleepiness in any case of work shifts and days off were classified as having SWSD. Additionally, 7 night shift workers participated in supplemental wrist actigraphy data collection for 7 to 8 days including 3 to 4 days of consecutive night shifts. Fourteen of 30 night shift workers were classified as having SWSD. Significant group differences were observed where the SWSD group felt that night shift work was harder and reported more frequent insomniac symptoms after a night shift. However, no other variables demonstrated remarkable differences between groups. Actigraphy results characterized 5 subjects reporting better perceived adaptation as having regular daytime sleep, for 6 to 9 h in total, between consecutive night shifts. On the other hand, 2 subjects reporting perceived maladaptation revealed different sleep patterns, with longer daytime sleep and large day-to-day variation in daytime sleep between consecutive night shifts, respectively. As the tasks for flight control require high levels of alertness and cognitive function, several characteristics, namely shift-working schedule (2 to 4 consecutive night shifts), very short break time (5 to 10 min/h) during work shifts, and cooperative work with onboard astronauts during the evening/night shift, accounted for increasing workloads especially in the case of night shifts, resulting in higher or equal prevalence of SWSD to that among other shift-working populations. Further studies are required to collect more actigraphy data and examine the possibility of interventions to improve SWSD.

29 May 2018 in Buildings
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Journal Article
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Kazuyo TsuzukiKazuyo Tsuzuki
Kazuyo Tsuzuki
KOKazue Okamoto-Mizuno
Kazue Okamoto-Mizuno
KMKoh Mizuno
Koh Mizuno
Most people do not use heating systems during nocturnal sleep in their bedrooms during the cold season in Japan; instead, they like to use extra blankets and quilts for sleeping. To investigate the effect of low air temperature (Ta) on sleep and thermoregulation when sleeping with bedding, 12 healthy young men participated in sleep experiments over three non-consecutive nights. The experimental conditions were at a Ta of 3 °C, 10 °C and 17 °C, with a relative humidity (Rh) of 50% and an air velocity of 94% for each of the three Tas, and no disturbances were found by Ta in the sleep parameters, although the duration of rapid eye movement (REM) sleep showed variations at 3 °C. The skin temperature (Ts) of the forehead decreased in proportion to Ta and remained stable. The decreasing rate in rectal temperature (Tre), Ts of forehead and thigh during sleep were significantly greater at 3 °C than at 10 °C and 17 °C. The innermost microclimate temperature (Tmicro) made by the bedding did not correlate with the Tre. The young men were significantly more dissatisfied with 3 °C in the sleep quality evaluation.

1 November 2002
Verified
Journal Article
Closed access
NKNorbert O Kraft
Norbert O Kraft
NINatsuhiko Inoue
Natsuhiko Inoue
KMKoh Mizuno
Koh Mizuno
HOHiroshi Ohshima
Hiroshi Ohshima
TMTadashi Murai
Tadashi Murai
CSChiharu Sekiguchi
Chiharu Sekiguchi

9 August 2019 in Clocks & Sleep
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Journal Article
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KMKoh Mizuno
Koh Mizuno
KOKazue Okamoto-Mizuno
Kazue Okamoto-Mizuno
KIKazuki Iwata
Kazuki Iwata
Although engaging in evening naps and extracurricular activities are popular among Japanese high school students, the associations between these behaviors and daytime sleep problems were unclear. A questionnaire on daily life and sleeping habits was administered to 1314 high school students, aged between 15–17 years. The respondents were categorized by their after-school napping habits (did not nap, napped 1–2 days/week, napped ≥3 days/week), and their extracurricular activities (no activity, cultural club, athletic club). The mean nocturnal sleep duration on weekdays (± standard deviation (SD)) was 390 ± 56 min. This was significantly shorter in those students with a higher number of days/week spent napping (p < 0.001), and slightly longer for those in the athletic club (p < 0.001). Sleep problems—including subjective insufficient sleep, excessive sleepiness during class ≥3 days/week, and falling asleep during class ≥3 days/week—were reported by 64%, 55%, and 33% of respondents, respectively. A multiple logistic regression analysis showed significantly higher risks for excessive sleepiness among students taking naps ≥3 days/week, and who belonged to athletic clubs. In addition to those factors, students in cultural clubs revealed significantly higher risks for falling asleep during classes. Future studies are required to decrease daytime sleep problems associated with evening naps and extracurricular activities among high school students.