General: modeling of neurological disorders using ex vivo transgenic and 3D cellular models, neurodegenerative disorders, transgenic animals, molecular mechanisms and pathways employed by neuronal cells to resist decease states and pathology Specific: aggregation-prone proteins and their role in development of neurodegenerative diseases, modeling of neurodegeneration and proteinopathies in mice. In brief: determination of pathways of neurodegenerative disorders and application of novel therapeutic agents to combat these disease states.