As the operational status of aircraft engines evolves, their fault modes also undergo changes. In response to the operational degradation trend of aircraft engines, this paper proposes an aircraft engine fault diagnosis model based on 1DCNN-BiLSTM with CBAM. The model can be directly applied to raw monitoring data without the need for additional algorithms to extract fault degradation features. It fully leverages the advantages of 1DCNN in extracting local features along the spatial dimension and incorporates CBAM, a channel and spatial attention mechanism. CBAM could assign higher weights to features relevant to fault categories and make the model pay more attention to them. Subsequently, it utilizes BiLSTM to handle nonlinear time feature sequences and bidirectional contextual feature information. Finally, experimental validation is conducted on the publicly available CMAPSS dataset from NASA, categorizing fault modes into three types: faultless, HPC fault (the single fault), and HPC&Fan fault (the mixed fault). Comparative analysis with other models reveals that the proposed model has a higher classification accuracy, which is of practical significance in improving the reliability of aircraft engine operations and for Remaining Useful Life (RUL) prediction.

Performance prediction based on candidates and screening based on predicted performance value are the core of product development. For example, the performance prediction and screening of equipment components and parts are an important guarantee for the reliability of equipment products. The prediction and screening of drug bioactivity value and performance are the keys to pharmaceutical product development. The main reasons for the failure of pharmaceutical discovery are the low bioactivity of the candidate compounds and the deficiencies in their efficacy and safety, which are related to the absorption, distribution, metabolism, excretion, and toxicity (ADMET) of the compounds. Therefore, it is very necessary to quickly and effectively perform systematic bioactivity value prediction and ADMET property evaluation for candidate compounds in the early stage of drug discovery. In this paper, a data-driven pharmaceutical products screening prediction model is proposed to screen drug candidates with higher bioactivity value and better ADMET properties. First, a quantitative prediction method for bioactivity value is proposed using the fusion regression of LGBM and neural network based on backpropagation (BP-NN). Then, the ADMET properties prediction method is proposed using XGBoost. According to the predicted bioactivity value and ADMET properties, the BVAP method is defined to screen the drug candidates. And the screening model is validated on the dataset of antagonized Erα active compounds, in which the mean square error (MSE) of fusion regression is 1.1496, the XGBoost prediction accuracy of ADMET properties are 94.0 for Caco-2, 95.7 for CYP3A4, 89.4 for HERG, 88.6 for hob, and 96.2 for Mn. Compared with the commonly used methods for ADMET properties such as SVM, RF, KNN, LDA, and NB, the XGBoost in this paper has the highest prediction accuracy and AUC value, which has better guiding significance and can help screen pharmaceutical product candidates with good bioactivity, pharmacokinetic properties, and safety.

The operational reliability of large mechanical equipment is typically influenced by the functional effectiveness of key components. Consequently, prompt repair before their failure is necessary to ensure the dependability of mechanical equipment. The prognostic and health management (PHM) technology could track the system’s health state and timely detect faults. Therefore, the remaining useful life (RUL) prediction as one of the key components of PHM is rather important. Accurate RUL prediction results could be the data support for condition-based equipment maintenance plans. Also, it could increase the dependability and safety of mechanical equipment while reducing the loss of human and financial resources and meet the requirements of sustainable manufacturing in the Industry 4.0 era. However, with the widespread use of deep learning in the field of intelligent manufacturing, there is a lack of review on RUL prediction based on deep learning. In this paper, different deep learning-based RUL prediction methods for mechanical components are summarized and classified, along with their pros and cons. Then, the case study on the C-MAPSS dataset is mainly conducted and different methods are compared. And finally, the difficulties and future directions of the RUL prediction in practical scenarios are discussed.

Spare parts are one of the important components of the equipment comprehensive support system. Spare parts management plays a decisive role in achieving the desired availability with the minimum cost. With the equipment complexity increasing, the price of spare parts has risen sharply. The traditional spare parts management makes the contradiction between fund shortage and spare parts shortage increasingly prominent. Based on the analysis of the multi-echelon and multi-indenture spare parts support model VARI-METRIC (vary multi-echelon technology for recoverable item control, VARI-METRIC), which is widely used by troops and enterprises in various countries, the model is mainly used in high system availability scenarios. However, in the case of low equipment system availability, the accuracy and cost of model inventory prediction are not ideal. This paper proposed the multi-level spare parts optimization model, which is based on the demand-supply steady-state process. It is an analytical model, which is used to solve the low accuracy problem of the VARI-METRIC model in the low equipment system availability. The analytical model is based on the multi-level spare parts support process. The article deduces methods for solving demand rate, demand–supply rate, equipment system availability, and support system availability. The marginal analysis method is used in the model to analyze the spare parts inventory allocation strategy’s current based cost and availability optimal value. Finally, a simulation model is established to evaluate and verify the model. Then, the simulation results show that, when the low availability of equipment systems are 0.4, 0.6, the relative errors of the analytical model are 3.54%, 3.86%, and its costs are 0.52, 1.795 million ¥ RMB. The experiment proves that the inventory prediction accuracy of the analytical model is significantly higher than that of the VARI-METRIC model in low equipment system availability. Finally, the conclusion and future research directions are discussed.

Large language models (LLMs) have been applied across various domains due to their superior natural language processing and generation capabilities. Noneth