Réda Hassen-Khodja

Prof. Réda Hassen-Khodja

Université Côte d’Azur, INSERM, C3M, Nice, France
+1
orcid

Research Focus & Metrics

Academic Career Length

41Years (1986-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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13 April 2017 in Nature Reviews Cardiology
Verified
Journal Article
Closed access
JRJuliette Raffort
Juliette Raffort
FLFabien Lareyre
Fabien Lareyre
MCMarc Clément
Marc Clément
RHRéda Hassen-Khodja
Réda Hassen-Khodja
GCGiulia Chinetti
Giulia Chinetti
ZMZiad Mallat
Ziad Mallat

3 February 2017 in British Journal of Surgery
Verified
Journal Article
Open access
PDF file
JPJ T Powell
J T Powell
MSM J Sweeting
M J Sweeting
PUP Ulug
P Ulug
JBJ D Blankensteijn
J D Blankensteijn
FLF A Lederle
F A Lederle
CCC Cousins
C Cousins
The erosion of the early mortality advantage of elective endovascular aneurysm repair (EVAR) compared with open repair of abdominal aortic aneurysm remains without a satisfactory explanation. An individual-patient data meta-analysis of four multicentre randomized trials of EVARversus open repair was conducted to a prespecified analysis plan, reporting on mortality, aneurysm-related mortality and reintervention. The analysis included 2783 patients, with 14 245 person-years of follow-up (median 5·5 years). Early (0–6 months after randomization) mortality was lower in the EVAR groups (46 of 1393 versus 73 of 1390 deaths; pooled hazard ratio 0·61, 95 per cent c.i. 0·42 to 0·89; P = 0·010), primarily because 30-day operative mortality was lower in the EVAR groups (16 deaths versus 40 for open repair; pooled odds ratio 0·40, 95 per cent c.i. 0·22 to 0·74). Later (within 3 years) the survival curves converged, remaining converged to 8 years. Beyond 3 years, aneurysm-related mortality was significantly higher in the EVAR groups (19 deaths versus 3 for open repair; pooled hazard ratio 5·16, 1·49 to 17·89; P = 0·010). Patients with moderate renal dysfunction or previous coronary artery disease had no early survival advantage under EVAR. Those with peripheral artery disease had lower mortality under open repair (39 deaths versus 62 for EVAR; P = 0·022) in the period from 6 months to 4 years after randomization. The early survival advantage in the EVAR group, and its subsequent erosion, were confirmed. Over 5 years, patients of marginal fitness had no early survival advantage from EVAR compared with open repair. Aneurysm-related mortality and patients with low ankle : brachial pressure index contributed to the erosion of the early survival advantage for the EVAR group. Trial registration numbers: EVAR-1, ISRCTN55703451; DREAM (Dutch Randomized Endovascular Aneurysm Management), NCT00421330; ACE (Anévrysme de l'aorte abdominale, Chirurgie versus Endoprothèse), NCT00224718; OVER (Open Versus Endovascular Repair Trial for Abdominal Aortic Aneurysms), NCT00094575.

1 September 2015 in European Journal of Vascular and Endovascular Surgery
Verified
Journal Article
Closed access
PDP. Desgranges
P. Desgranges
HKH. Kobeiter
H. Kobeiter
SKS. Katsahian
S. Katsahian
MBM. Bouffi
M. Bouffi
PGP. Gouny
P. Gouny
JBJ.-P. Becquemin
J.-P. Becquemin

1 July 2017 in JACC: Cardiovascular Interventions
Verified
Journal Article
Closed access
YGYann Gouëffic
Yann Gouëffic
NSNellie Della Schiava
Nellie Della Schiava
FTFabien Thaveau
Fabien Thaveau
EREugenio Rosset
Eugenio Rosset
JFJean-Pierre Favre
Jean-Pierre Favre
BNBahaa Nasr
Bahaa Nasr

1 August 2008 in European Journal of Vascular and Endovascular Surgery
Verified
Journal Article
Closed access
MBM. Batt
M. Batt
EJE. Jean-Baptiste
E. Jean-Baptiste
SOS. O'COnnor
S. O'COnnor
PBP.-J. Bouillanne
P.-J. Bouillanne
PHP. Haudebourg
P. Haudebourg
RFR. Farhad
R. Farhad

1 July 2014 in Journal of Vascular Surgery
Verified
Journal Article
Closed access
EJElixène Jean-Baptiste
Elixène Jean-Baptiste
SBSophie Brizzi
Sophie Brizzi
MBMichel A. Bartoli
Michel A. Bartoli
NSNirvana Sadaghianloo
Nirvana Sadaghianloo
JBJean Baqué
Jean Baqué
RHRéda Hassen-Khodja
Réda Hassen-Khodja