The rapid development of Artificial Intelligence (AI) technology has enabled the deployment of various systems based on it. However, many current AI systems are found vulnerable to imperceptible attacks, biased against underrepresented groups, lacking in user privacy protection. These shortcomings degrade user experience and erode people’s trust in all AI systems. In this review, we provide AI practitioners with a comprehensive guide for building trustworthy AI systems. We first introduce the theoretical framework of important aspects of AI trustworthiness, including robustness, generalization, explainability, transparency, reproducibility, fairness, privacy preservation, and accountability. To unify currently available but fragmented approaches toward trustworthy AI, we organize them in a systematic approach that considers the entire lifecycle of AI systems, ranging from data acquisition to model development, to system development and deployment, finally to continuous monitoring and governance. In this framework, we offer concrete action items for practitioners and societal stakeholders (e.g., researchers, engineers, and regulators) to improve AI trustworthiness. Finally, we identify key opportunities and challenges for the future development of trustworthy AI systems, where we identify the need for a paradigm shift toward comprehensively trustworthy AI systems.

Instance segmentation is of great importance for many biological applications, such as study of neural cell interactions, plant phenotyping, and quantitatively measuring how cells react to drug treatment. In this paper, we propose a novel box-based instance segmentation method. Box-based instance segmentation methods capture objects via bounding boxes and then perform individual segmentation within each bounding box region. However, existing methods can hardly differentiate the target from its neighboring objects within the same bounding box region due to their similar textures and low-contrast boundaries. To deal with this problem, in this paper, we propose an object-guided instance segmentation method. Our method first detects the center points of the objects, from which the bounding box parameters are then predicted. To perform segmentation, an object-guided coarse-to-fine segmentation branch is built along with the detection branch. The segmentation branch reuses the object features as guidance to separate target object from the neighboring ones within the same bounding box region. To further improve the segmentation quality, we design an auxiliary feature refinement module that densely samples and refines point-wise features in the boundary regions. Experimental results on three biological image datasets demonstrate the advantages of our method. The code will be available at https://github.com/yijingru/ObjGuided-Instance-Segmentation.

Multiple Instance Learning (MIL) represents the predominant framework in Whole Slide Image (WSI) classification, covering aspects such as sub-typing, diagnosis, and beyond. Current MIL models predominantly rely on instance-level features derived from pretrained models such as ResNet. These models segment each WSI into independent patches and extract features from these local patches, leading to a significant loss of global spatial context and restricting the model's focus to merely local features. To address this issue, we propose a novel MIL framework, named SAM-MIL, that emphasizes spatial contextual awareness and explicitly incorporates spatial context by extracting comprehensive, image-level information. The Segment Anything Model (SAM) represents a pioneering visual segmentation foundational model that can capture segmentation features without the need for additional fine-tuning, rendering it an outstanding tool for extracting spatial context directly from raw WSIs. Our approach includes the design of group feature extraction based on spatial context and a SAM-Guided Group Masking strategy to mitigate class imbalance issues. We implement a dynamic mask ratio for different segmentation categories and supplement these with representative group features of categories. Moreover, SAM-MIL divides instances to generate additional pseudo-bags, thereby augmenting the training set, and introduces consistency of spatial context across pseudo-bags to further enhance the model's performance. Experimental results on the CAMELYON-16 and TCGA Lung Cancer datasets demonstrate that our proposed SAM-MIL model outperforms existing mainstream methods in WSIs classification. Our open-source implementation code is is available at https://github.com/FangHeng/SAM-MIL.

Real-world data consistently exhibits a long-tailed distribution, often spanning multiple categories. This complexity underscores the challenge of content comprehension, particularly in scenarios requiring Long-Tailed Multi-Label image Classification (LTMLC). In such contexts, imbalanced data distribution and multi-object recognition pose significant hurdles. To address this issue, we propose a novel and effective approach for LTMLC, termed Category-Prompt Refined Feature Learning (CPRFL), utilizing semantic correlations between different categories and decoupling category-specific visual representations for each category. Specifically, CPRFL initializes category-prompts from the pretrained CLIP's embeddings and decouples category-specific visual representations through interaction with visual features, thereby facilitating the establishment of semantic correlations between the head and tail classes. To mitigate the visual-semantic domain bias, we design a progressive Dual-Path Back-Propagation mechanism to refine the prompts by progressively incorporating context-related visual information into prompts. Simultaneously, the refinement process facilitates the progressive purification of the category-specific visual representations under the guidance of the refined prompts. Furthermore, taking into account the negative-positive sample imbalance, we adopt the Asymmetric Loss as our optimization objective to suppress negative samples across all classes and potentially enhance the head-to-tail recognition performance. We validate the effectiveness of our method on two LTMLC benchmarks and extensive experiments demonstrate the superiority of our work over baselines.The code is available at https://github.com/jiexuanyan/CPRFL.

Position bias, the phenomenon whereby users tend to focus on higher-ranked items of the search result list regardless of the actual relevance to queries, is prevailing in many ranking systems. Position bias in training data biases the ranking model, leading to increasingly unfair item rankings, click-through-rate (CTR), and conversion rate (CVR) predictions. To jointly mitigate position bias in both item CTR and CVR prediction, we propose two position-bias-free CTR and CVR prediction models: Position-Aware Click-Conversion (PACC) and PACC via Position Embedding (PACC-PE). PACC is built upon probability decomposition and models position information as a probability. PACC-PE utilizes neural networks to model product-specific position information as embedding. Experiments on the E-commerce sponsored product search dataset show that our proposed models have better ranking effectiveness and can greatly alleviate position bias in both CTR and CVR prediction.