INSERM senior Scientist, TAGC/INSERM U1090 https://orcid.org/0000-0002-6734-4479. research project : Identification of genetic variants regulating humoral and cytotoxic immune responses: potential impact in risk stratification during sepsis, malaria, Chagas cardiomyopathy and haematological diseases. Recent advances identify the role of non coding genetic variants in the control of transcription of checkpoint inhibitory molecules, thus affecting the balance of activating/inhibiting signals that condition the inter-individual variability of host immune response to pathogens and tumors. ChatGPT Recent advances reveal the role of non-coding genetic variants in immune gene regulation. These mutations impact the transcription of checkpoint inhibitory molecules, influencing the balance of immune signals affecting individual responses to pathogens and tumors. Previous studies (10.3389/fimmu.2019.01208, hal-02305291; 10.1161/CIRCULATIONAHA.117.030435, hal-01634563) identified FCGR3A/CD16 and FCGR2A/CD32a variants as immune activation predictors. Our research focuses on 1/ identifying regulatory variants affecting immune gene clusters (FCGR, FCGRT, LST1/NCR3, LILRB1) encoding checkpoint receptors. 2/ validating these variants as immune escape drivers and disease outcome predictors, with TAGC Axis 2 pathologies in mind (Malaria, Chagas Cardiopathy, hematological Malignancies).