Capsules with shells based on nanoparticles of different nature co-assembled at the interface of liquid phases of emulsion are promising carriers of lipophilic drugs. To obtain such capsules, theoretically using the Derjaguin–Landau–Verwey–Overbeek (DLVO) theory and experimentally using dynamic light-scattering (DLS) and transmission electron microscopy (TEM) methods, the interaction of like-charged silica nanoparticles and detonation nanodiamonds in an aqueous solution was studied and their ratios selected for the formation of submicron-sized colloidosomes. The resulting colloidosomes were modified with additional layers of nanoparticles and polyelectrolytes, applying LbL technology. As a model anti-cancer drug, thymoquinone was loaded into the developed capsules, demonstrating a significant delay of the release as a result of colloidosome surface modification. Fluorescence flow cytometry and confocal laser scanning microscopy showed efficient internalization of the capsules by MCF7 cancer cells. The obtained results demonstrated a high potential for nanomedicine application in the field of the drug-delivery system development.

Particles of natural hydrothermal nanosilica have been characterized, and the conditions of their self-organization have been chosen for the stabilization of oil-in-water emulsions with the use of a cationic surfactant. Microcapsules, which consist of shells composed of layer-by-layer deposited chitosan and calcium alginate and contain dodecane, soybean and sesame oils, a 30% α-tocopherol acetate solution in sunflower oil, and shea butter, have been prepared on the basis of Pickering emulsions. Conclusions on the mechanical stability of the Pickering emulsions and capsules based thereon have been inferred from changes occurring in the colloidal system as a result of centrifugation at 27 000g. The capsules with the vegetable oils have exhibited a higher stability than those containing dodecane. The three-layer polymer shell has been shown to prevent the nanocapsules from coalescence and breakage upon centrifugation.

Microcapsules with shells of natural silica nanoparticles are obtained based on the Pickering emulsion and polyelectrolyte layers of chitosan and alginate. The stable emulsions are created by the...

The stabilization of Pickering emulsions with mixtures of similarly or oppositely charged detonation nanodiamonds and silica nanoparticles has been studied. Dynamic light scattering has been employed to study the influence of pH and the mass ratio of the particles on the sizes and ζ-potentials of aggregates. The formation of heteroaggregates from mixtures of similarly charged nanoparticles and the efficient stabilization of dodecane droplets have been shown and theoretically substantiated. Submicron droplets of Pickering emulsion stabilized with the mixtures of oppositely charged silica nanoparticles and detonation nanodiamonds have been obtained.