In recent years, the concepts of teleconnections and telecoupling have been introduced into land-use and land-cover change literature as frameworks that seek to explain connections between areas that are not in close physical proximity to each other. The conceptual frameworks of teleconnections and telecoupling seek to explicitly link land changes in one place, or in a number of places, to distant, usually non-physically connected locations. These conceptual frameworks are offered as new ways of understanding land changes; rather than viewing land-use and land-cover change through discrete land classifications that have been based on the idea of land-use as seen through rural–urban dichotomies, path dependencies and sequential land transitions, and place-based relationships. Focusing on the land-use and land-cover changes taking place along the East–West Economic Corridor that runs from Dong Ha City in Quang Tri, Vietnam, through Sepon District, Savannakhet, Lao PDR, into Thailand this paper makes use of data gathered from fieldwork and remote sensing analysis to examine telecouplings between sending, receiving and spill-over systems on both sides of the Vietnam-Lao PDR border. Findings are that the telecouplings are driving changes in rural village and urban systems on both sides of the border, and are enabled by a policy environment that has sought to facilitate the cross-border transportation of goods within the region.