Diana Madelen Galindres Jiménez

Prof. Dr. Diana Madelen Galindres Jiménez


Research Focus & Metrics

Academic Career Length

5Years (2022-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

View All Publications
31 March 2022 in Processes
Verified
Journal Article
Open access
PDF file
DJDiana Madelen Galindres Jiménez
Diana Madelen Galindres Jiménez
DCDiego Cifuentes
Diego Cifuentes
LRLuz Elena Tinoco Robledo
Luz Elena Tinoco Robledo
YMYesid Sneider Murillo
Yesid Sneider Murillo
MRM. Melia Rodrigo
M. Melia Rodrigo
Miguel A EstesoMiguel A Esteso
Miguel A Esteso
Due to the diseases that people face today, scientists dedicate a part of their research to the synthesis, characterization, and study of functional compounds for controlled drug delivery. On the one hand, resorcinarenes are macrocycles obtained by condensation reactions of resorcinol and aldehyde. They include an upper and a lower rim functioning with different groups that confer solubility to the macrocycle and favor interactions with other compounds, therefore the hydroxyl groups on the upper rim improve the formation of hydrogen bonds. Additionally, resorcinarenes feature a cavity studied for forming host-guest complexes. SBA-15, on the other hand, is a mesoporous silica characterized by ordered pores in its structure and a large surface area. As a result of its properties, it has been used for several purposes, including absorbents, drug delivery, catalysis, and environmental processes. This review shows the recent advances in synthesis methods, characterization, micelle formation, interaction with other compounds, and host-guest procedures, as well as techniques for evaluating toxicity, drug retention, and their preliminary uses in pharmacology for macrocycles, such as resorcin[4]arenes and SBA-15.

Verified
Journal Article
Open access
PDF file
DJDiana Madelen Galindres Jiménez
Diana Madelen Galindres Jiménez
NENicolás Espitia-Galindo
Nicolás Espitia-Galindo
Artur ValenteArtur Valente
Artur Valente
SSSara Sofio
Sara Sofio
MRM. Melia Rodrigo
M. Melia Rodrigo
Ana RibeiroAna Ribeiro
Ana Ribeiro
The interaction between sodium salicylate (NaSal) and the two macrocycles 5,11,17,23-tetrakissulfonatomethylene-2,8,14,20-tetra(ethyl)resorcinarene (Na4EtRA) and β-cyclodextrin (β-CD) has been studied by the determination of ternary mutual diffusion coefficients, and spectroscopic and computational techniques. The results obtained by the Job method suggest that the complex formation is given in a 1:1 ratio for all systems. The mutual diffusion coefficients and the computational experiments have shown that the β-CD-NaSal system presents an inclusion process, whereas the Na4EtRA-NaSal system forms an outer-side complex. This fact is also in line with the results obtained from the computational experiments, where the calculated solvation free energy has been found to be more negative for the Na4EtRA-NaSal complex because of the partial entry of the drug inside the Na4EtRA cavity.

17 November 2023 in Preprints.org
Verified
Preprint
Open access
PDF file
CHCarlos Felipe Herrera-Puerta
Carlos Felipe Herrera-Puerta
SSSantiago Suspes-García
Santiago Suspes-García
DJDiana Madelen Galindres Jiménez
Diana Madelen Galindres Jiménez
DCDiego Cifuentes-Galindres
Diego Cifuentes-Galindres
LRLuz Elena Tinoco Robledo
Luz Elena Tinoco Robledo
YMYesid Sneider Murillo
Yesid Sneider Murillo
Smoked cigarette butts (SCB) can be used as precursors to obtain activated carbon (AC) due to their high carbon content related to the presence of cellulose acetate and components that are retained in the tobacco combustion process. In this way, it was analyzed how the process of pyrolysis or formation of char from this residue occurs, for this a study of the kinetics of formation of char is carried out by thermogravimetry, using three heating speeds 5, 10 and 15 °C/min. Based on the data obtained, mathematical models such as Kissenger - Akahira - Sunose (KAS), Starink (STK) and Ozawa - Flynn - Wall (OFW) were used in order to identify thermodynamic parameters through the energy of activation. The char obtained was subjected to an activation treatment with KOH in order to increase the surface area and pore volume, obtaining values of 433 m2/g of BET area and 0.25 cm3/g of micropore volume. Finally, the adsorbent was applied in the removal of Cr (VI) obtaining a Qmax capacity determined by the Langmuir model of 55.8 mg/g.