Novel pyrrolo [2,3-b] pyrrole derivatives were synthesized and their hypolipidemic activity was assessed in hyperlipidemic rats. The chemical structures of the new derivatives were confirmed through spectral analysis. Compounds 5 and 6 were revealed to be the most effective hypolipidemic agents, with considerable hypocholesterolemic and hypotriglyceridemic effects. They appear to be promising candidates for creating new powerful derivatives with anti-atherosclerotic and hypolipidemic properties. As for antimicrobial activity, some of the tested compounds showed moderate activity against Pseudomonas aeruginosa: compound 2 revealed an MIC value of 50 μg/mL, compared to 25 μg/mL for ciprofloxacin. Compound 3 showed good antimicrobial activity against Staphylococcus aureus, comparable to ciprofloxacin, and roughly half the activity of ampicillin, according to MIC values. Compound 2 has an MIC approximately 25% of that of clotrimazole against Candida albicans. Compound 2 also showed the highest antioxidant activity with 59% inhibition of radical scavenging activity. Additionally, the cytotoxic activity of these new derivatives 1–7 was investigated and most of them showed good anticancer activity against the three tested cell lines.

Pure and lightly Zn-doped (MoS₂)_0.97Zn_0.03 powdered samples have been prepared by a simple economic method, structurally analysed by XRD, FT-IR, XPS, SEM& EDX, and optically characterised using optical diffuse reflectance spectroscopy. XRD analysis of the heat-treated Zn: MoS₂ product revealed the formation of different multi-heterojunction semiconducting MoS₂, MoO₃ and barely visible ZnS components beside the metal-Zn element which were confirmed by FT-IR, XPS& EDX. The crystallite size for MoS₂ samples decreased from 400.465 to 326.179 nm of (MoS₂)_0.97Zn_{0.03 ,} while the MoO₃ and Zn constituents exhibit lower values of 108.884 & 8.045 nm, respectively. Their porosity percentages of ∼60%–67% are relatively high and beneficial for the photocatalytic process. The optical study showed a indirect allowed band gap with energy values of 1.2 and 0.9 eV for undoped and Zn doped, respectively. The photocatalytic study has been performed at different MB concentrations (10–20 ppm), and catalyst amounts (0.04–0.1 g) under dark, UV, and Vis irradiations assisted by pH and/or ultrasonic piezoelectric potential. The current enhanced result of 99.3% efficiency and a high performance figure of merit of ∼1045 min⁻¹ were achieved in 20 s for (MoS₂)_0.97Zn_0.03 with the capability of reusability.