This study aims at high-frequency ultrasound image quality assessment for computer-aided diagnosis of skin. In recent decades, high-frequency ultrasound imaging opened up new opportunities in dermatology, utilizing the most recent deep learning-based algorithms for automated image analysis. An individual dermatological examination contains either a single image, a couple of pictures, or an image series acquired during the probe movement. The estimated skin parameters might depend on the probe position, orientation, or acquisition setup. Consequently, the more images analyzed, the more precise the obtained measurements. Therefore, for the automated measurements, the best choice is to acquire the image series and then analyze its parameters statistically. However, besides the correctly received images, the resulting series contains plenty of non-informative data: Images with different artifacts, noise, or the images acquired for the time stamp when the ultrasound probe has no contact with the patient skin. All of them influence further analysis, leading to misclassification or incorrect image segmentation. Therefore, an automated image selection step is crucial. To meet this need, we collected and shared 17,425 high-frequency images of the facial skin from 516 measurements of 44 patients. Two experts annotated each image as correct or not. The proposed framework utilizes a deep convolutional neural network followed by a fuzzy reasoning system to assess the acquired data’s quality automatically. Different approaches to binary and multi-class image analysis, based on the VGG-16 model, were developed and compared. The best classification results reach $91.7\%$ accuracy for the first, and $82.3\%$ for the second analysis, respectively.

The paper presents the multistep methodology of bimodal Patient Specific Phantom (PSP) development. First, CT based abdominal digital model is designed. It serves as a source for designing organ moulds manufactured by means of a 3D-printer. The collagen based colloid fills the moulds yielding the organ casts. The PSP permits a bimodal navigation system to be developed that employs a realistic CT-based digital model and US imaging. Highly accurate results were achieved with mean Dice similarity coefficient value of 0.92 and Hausdorff distance 9.67 mm.

A growing number of medical applications, including minimal invasive surgery, depends on multi-modal or multi-sensors data processing. Fast and accurate 3D scene analysis, comprising data registration, seems to be crucial for the development of computer aided diagnosis and therapy. The advancement of surface tracking system based on optical trackers already plays an important role in surgical procedures planning. However, new modalities, like the time-of-flight (ToF) sensors, widely explored in non-medical fields are powerful and have the potential to become a part of computer aided surgery set-up. Connection of different acquisition systems promises to provide a valuable support for operating room procedures. Therefore, the detailed analysis of the accuracy of such multi-sensors positioning systems is needed. We present the system combining pre-operative CT series with intra-operative ToF-sensor and optical tracker point clouds. The methodology contains: optical sensor set-up and the ToF-camera calibration procedures, data pre-processing algorithms, and registration technique. The data pre-processing yields a surface, in case of CT, and point clouds for ToF-sensor and marker-driven optical tracker representation of an object of interest. An applied registration technique is based on Iterative Closest Point algorithm. The experiments validate the registration of each pair of modalities/sensors involving phantoms of four various human organs in terms of Hausdorff distance and mean absolute distance metrics. The best surface alignment was obtained for CT and optical tracker combination, whereas the worst for experiments involving ToF-camera. The obtained accuracies encourage to further develop the multi-sensors systems. The presented substantive discussion concerning the system limitations and possible improvements mainly related to the depth information produced by the ToF-sensor is useful for computer aided surgery developers.