Zhitong Chen

Prof. Dr. Zhitong Chen

1. Center for Advanced Therapy, National Innovation Center for Advanced Medical Devices, Shenzhen 518000, China
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Research Focus & Metrics

Academic Career Length

17Years (2010-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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12 January 2020 in Advances in Polymer Technology
Verified
Journal Article
Open access
PDF file
GPGuangjian Peng
Guangjian Peng
GDGuijing Dou
Guijing Dou
YHYahao Hu
Yahao Hu
YSYiheng Sun
Yiheng Sun
Zhitong ChenZhitong Chen
Zhitong Chen
Phase change materials (PCMs) are gaining increasing attention and becoming popular in the thermal energy storage field. Microcapsules enhance thermal and mechanical performance of PCMs used in thermal energy storage by increasing the heat transfer area and preventing the leakage of melting materials. Nowadays, a large number of studies about PCM microcapsules have been published to elaborate their benefits in energy systems. In this paper, a comprehensive review has been carried out on PCM microcapsules for thermal energy storage. Five aspects have been discussed in this review: classification of PCMs, encapsulation shell materials, microencapsulation techniques, PCM microcapsules’ characterizations, and thermal applications. This review aims to help the researchers from various fields better understand PCM microcapsules and provide critical guidance for utilizing this technology for future thermal energy storage.

1 November 2020 in Physics of Fluids
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Journal Article
Closed access
PDF file
Zhitong ChenZhitong Chen
Zhitong Chen
GGGustavo Garcia
Gustavo Garcia
VAVaithilingaraja Arumugaswami
Vaithilingaraja Arumugaswami
Richard E. WirzRichard E. Wirz
Richard E. Wirz
Syndrome coronavirus 2 (SARS-CoV-2) infectious virions are viable on various surfaces (e.g., plastic, metals, and cardboard) for several hours. This presents a transmission cycle for human infection that can be broken by developing new inactivation approaches. We employed an efficient cold atmospheric plasma (CAP) with argon feed gas to inactivate SARS-CoV-2 on various surfaces including plastic, metal, cardboard, basketball composite leather, football leather, and baseball leather. These results demonstrate the great potential of CAP as a safe and effective means to prevent virus transmission and infections for a wide range of surfaces that experience frequent human contact. Since this is the first-ever demonstration of cold plasma inactivation of SARS-CoV-2, it is a significant milestone in the prevention and treatment of coronavirus disease 2019 (COVID-19) and presents a new opportunity for the scientific, engineering, and medical communities.

30 May 2017 in Cancers
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Journal Article
Open access
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Zhitong ChenZhitong Chen
Zhitong Chen
HSHayk Simonyan
Hayk Simonyan
XCXiaoqian Cheng
Xiaoqian Cheng
EGEda Gjika
Eda Gjika
Lin LiLin Li
Lin Li
Michael KeidarMichael Keidar
Michael Keidar
Cold atmospheric plasma (CAP) treatment is a rapidly expanding and emerging technology for cancer treatment. Direct CAP jet irradiation is limited to the skin and it can also be invoked as a supplement therapy during surgery as it only causes cell death in the upper three to five cell layers. However, the current cannulas from which the plasma emanates are too large for intracranial applications. To enhance efficiency and expand the applicability of the CAP method for brain tumors and reduce the gas flow rate and size of the plasma jet, a novel micro-sized CAP device (µCAP) was developed and employed to target glioblastoma tumors in the murine brain. Various plasma diagnostic techniques were applied to evaluate the physics of helium µCAP such as electron density, discharge voltage, and optical emission spectroscopy (OES). The direct and indirect effects of µCAP on glioblastoma (U87MG-RedFluc) cancer cells were investigated in vitro. The results indicate that µCAP generates short- and long-lived species and radicals (i.e., hydroxyl radical (OH), hydrogen peroxide (H2O2), and nitrite (NO2−), etc.) with increasing tumor cell death in a dose-dependent manner. Translation of these findings to an in vivo setting demonstrates that intracranial µCAP is effective at preventing glioblastoma tumor growth in the mouse brain. The µCAP device can be safely used in mice, resulting in suppression of tumor growth. These initial observations establish the µCAP device as a potentially useful ablative therapy tool in the treatment of glioblastoma.

3 September 2021 in Science Advances
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Journal Article
Open access
GCGuojun Chen
Guojun Chen
Zhitong ChenZhitong Chen
Zhitong Chen
ZWZejun Wang
Zejun Wang
RORichard Obenchain
Richard Obenchain
DWDi Wen
Di Wen
ZGZhen Gu
Zhen Gu
A portable air-fed cold atmospheric plasma device was invented for postsurgical cancer immunotherapy to inhibit tumor relapse.

24 November 2016 in Journal of Physics D: Applied Physics
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Journal Article
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Zhitong ChenZhitong Chen
Zhitong Chen
XCXiaoqian Cheng
Xiaoqian Cheng
LLLi Lin
Li Lin
Michael KeidarMichael Keidar
Michael Keidar
Cold atmospheric plasma (CAP) has emerged as a novel technology for cancer treatment. CAP can directly treat cells and tissue but such direct application is limited to skin or can be invoked as a supplement during open surgery. In this study we report indirect plasma treatment using CAP discharged in deionized (DI) water using three gases as carriers (argon (Ar), helium (He), and nitrogen (N 2 )). Plasma stimulated water was applied to the human breast cancer cell line (MDA-MB-231). MTT (3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay tests showed that using Ar plasma had the strongest effect on inducing apoptosis in cultured human breast cancer cells. This result is attributed to the elevated production of reactive oxygen species and reactive nitrogen species in water.

24 October 2016 in Plasma Processes and Polymers
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Journal Article
Closed access
PDF file
Zhitong ChenZhitong Chen
Zhitong Chen
LLLi Lin
Li Lin
XCXiaoqian Cheng
Xiaoqian Cheng
EGEda Gjika
Eda Gjika
Michael KeidarMichael Keidar
Michael Keidar